Medicine

ENGLISH

Laboratory Experiments Using Microwave Heating

by Cynthia B. Mcgowan e Nicholas E. Leadbeater

125,86€ + 10% CARD

 Allowing many chemical reactions to be completed within minutes, microwave heating has revolutionized preparative chemistry. As a result, this technology has been widely adopted in both academic and industrial laboratories. Integrating microwave-assisted chemistry into undergraduate laboratory courses enables students to perform a broader range of reactions in the allotted lab period. As a result, they can be introduced to chemistry that would otherwise have been inaccessible due to time constraints (for example, the need for an overnight reflux). Laboratory Experiments Using Microwave Heating provides 22 experiments encompassing organic, inorganic, and analytical chemistry performed using microwave heating as a tool, making them fast and easy to accomplish in a laboratory period. Utilizing the time-saving experiments described in this book also permits students to repeat experiments if necessary or attempt additional self-designed experiments during the lab course.A number of the chemical transformations use water as a solvent in lieu of classical organic solvents. This contributes to greener, more sustainable teaching strategies for faculty and students, while maintaining high reaction yields. All the experiments have been tested and verified in laboratory classes, and many were even developed by students. Each chapter includes an introduction to the experiment and two protocols-one for use with a smaller monomode microwave unit employing a single reaction vessel and one for use with a larger multimode microwave unit employing a carousel of reaction vessels.
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Key Heterocyclic Cores For Smart Anticancer Drug-Design Part Ii

eBook 10%

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Key Heterocyclic Cores For Smart Anticancer Drug-Design Part Ii

56,45€ + 10% CARD

 This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design.Part 2 of the book set covers these topics:- Anticancer targets for heterocyclic lead compounds- Coumarin hybrids for cancer treatments- Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity- Imidazole as an anticancer heterocyclic ring- Morpholine for profiling anticancer lead compounds- Natural products as anticancer agents
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Pharmaceutical Product Development - Insights Into Pharmaceutical Processes, Management And Regulatory Affairs

67,56€ + 10% CARD

 This book equips the pharmaceutical formulation scientist with extensive and up-to-date knowledge of drug product development and covers all steps from the beginning of product conception to the final packaged form that enters the market and lifecycle management thereof. Applications of core science principles.
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Advanced Drug Delivery Strategies Via Microbial Cargos And Their Derivatives

eBook 10%

ENGLISH

Advanced Drug Delivery Strategies Via Microbial Cargos And Their Derivatives

~~238,50€~~ 214,65€ 10% OFF

 Overviews various aspects of microbial drug delivery systems as well as insights on strategies for the development of innovative microbial cargos using properties of microorganisms and their derivatives. Discusses topics like bacterial cellulose-based drug delivery systems, virus-based drug delivery systems, and more.
ENGLISH

Synthesis Of Best-Seller Drugs - Volume 2

by Gayane Vardanyan e Ruben Vardanyan

~~169,59€~~ 152,63€ 10% OFF

 Synthesis of Best-Seller Drugs, Volume Two, Second Edition provides detailed information on the most popular drugs using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas while also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts while also encouraging future developments in this important field. - Presents over 500 detailed synthetic routes to manufacture drugs- Describes the methods of synthesis, bioactivity, and related drugs for all drug types- Examines the chemistry and mode of action of over 700 drugs
ENGLISH

Herb-Drug Interactions From A To Z - A Guide For Health Care Professionals And The Public Volume 1

by Ayse Kuruuzum-Uz, Bilge Sener, L. Omur Demirezer e Tayfun Ersoz

~~152,38€~~ 137,14€ 10% OFF

 This volume provides information about herb-drug interactions that may arise as a result of the increasing interest in medicinal plants or herbal products and the concomitant use of conventional drugs. It also highlights evidence on herb-drug interactions from a systematic review, providing rapid access to information on their clinical use.
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Science And Applications Of 3d Bioprinting

~~172,25€~~ 155,03€ 10% OFF

 3D bioprinting offers the potential to revolutionize regenerative medicine, drug development, and personalized healthcare. The Science and Applications of 3D Printing explores the science of 3D bioprinting, covering the advancements in materials, techniques, and applications and serves as a comprehensive guide to this emerging field.
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Clinical Audit In Pharmaceutical Development

90,09€ + 10% CARD

 Detailing the need for, and stressing the importance of, an audit of clinical data to protect participants and validate study results. This book examines the use of computers, the Internet, and third-party organizations to assist in data validation. It positions the audit as a tool to verify that a drug is safe and effective in clinical trials.
ENGLISH

Mosby'S Drug Guide For Nursing Students - E-Book

by Linda Skidmore-Roth

~~46,36€~~ 41,72€ 10% OFF

 Find the information you need to administer drugs safely, accurately, and professionally! Mosby's Drug Guide for Nursing Students, 17th Edition with 2027 Update, provides concise profiles of more than 4,000 generic and trade-name drugs, including the drugs most recently approved by the FDA. Each drug monograph includes clear guidelines for dosing, administration, and the nursing process, so you'll always be sure that you're prioritizing medication safety. What sets this handbook apart is its detailed coverage of rationales and explanations, IV drugs, and the similarities and differences in common classes of drugs. From well-known nursing and pharmacology expert Linda Skidmore-Roth, this drug guide has been trusted by nursing students for more than 25 years!- Up-to-date information on drug dosages, researched adverse effects, Black Box Warnings, nursing considerations, and patient education helps ensure you have access to the best evidence-based medicine- Content on more than 4,000 generic and trade name drugs provides coverage for almost every drug you are likely to encounter in clinicals- Black Box Warning feature alerts you to FDA warnings of potentially life-threatening reactions- Safety Alert icon highlights the most critical interactions and side effects that you must be aware of during clinicals- Bold headings and details on IV drug administration help you easily find appropriate dosage and IV administration instructions for safe drug administration- Side effects information is logically organized by body system and is identified as common or life-threatening, showing you what signs to watch for during assessments. - Nursing Process framework presents nursing care information to help you learn to easily and completely incorporate the nursing process into your clinical experiences- Alphabetical organization by generic name, with both trade and generic names in the index, gives you quick access to specific drugs- Complete pharmacokinetic information tables explain the mechanism and absorption of each drug, as well as the action, duration, and excretion of the drug- Cross-reference headers in the book direct you to drugs found in the appendices, making it easier to quickly find drug content- NEW! Up-to-date coverage includes 20-30 monographs on newly released, FDA-approved drugs and content on the latest drug therapies- NEW! Special QR code links to a website containing additional online-only drug monographs
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Antimicrobial Therapeutics And Drug Discovery

~~182,84€~~ 164,56€ 10% OFF

 Antimicrobial Therapeutics and Drug Discovery is a comprehensive resource that provides an overview of antimicrobial drug discovery. It covers a wide spectrum of pathogenic organisms causing human infections, exploring alternative therapeutic strategies beyond traditional small molecule drugs. The contents in the book are structured into four parts, each focusing on a different aspect of antimicrobial drug discovery. From exploring viral and host targets, understanding antibiotic resistance mechanisms, to the potential of nanomedicine and computational approaches, the book offers a comprehensive view of the field. Employing a multidisciplinary approach, chapters discuss the importance of drug discovery for fungi, Mycobacteria, Mycoplasma, and parasites, and offers insights into innovative biomedical approaches and combination therapies. By bridging the gap between experimental research and practical application, Antimicrobial Therapeutics and Drug Discovery is a key reference for pharmacologists and pharmaceutical scientists working in academic and corporate research. Medicinal chemists and microbiologists will also benefit from the multidisciplinary coverage of the book. - Provides a comprehensive overview of antimicrobial drug discovery- Discusses ethical imperatives in combating antimicrobial resistance- Offers insights into drug discovery for overlooked pathogens- Explores alternative therapeutic strategies for combating antibiotic resistance- Bridges the gap between experimental research and practical application
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Unofficial Guide To Prescribing E-Book - The Unofficial Guide To Prescribing E-Book

~~37,09€~~ 33,38€ 10% OFF

 Part of the unique and award-winning The Unofficial Guides series, a collaboration between senior students, junior doctors and specialty experts. This combination of contributors understands what is essential to excel on your course, in exams and in practice - as well as the importance of presenting information in a clear, fun and engaging way. Packed with hints and tips from those in the know, when you are in a hurry and need a study companion you can trust, reach for an Unofficial Guide.The Unofficial Guide to Prescribing provides detailed steps on patient assessment, investigation, and management, with an emphasis on prescription procedures. Through clinical scenarios, this work provides the necessary skills to excel in handling emergencies and complex prescribing.Prescribing errors have significant health implications for patients and financial implications for healthcare systems, costing millions annually. As such, early prescribing training has become a crucial necessity in medical education and is now an integral part of teaching and assessment.Each scenario is presented as you would see it in the hospital setting and covers:- Initial step-by-step assessment of the patient: how to assess, assessment findings, and immediate management- Initial investigations- Initial management- Reassessment- Treatment- Handing over the patient- New section on electronic prescribing and fluid prescribing- Drug charts throughout to fill in with model answers- Core theory around prescribing alongside practical application- Prescribing taught alongside clinical management
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Handbook Of Evidence-Based Pharmacist Care: Clinical, Economic, And Humanistic Impact - Volume 13: Pharmacist Skills And Competencies

by Yaser Mohammed Al-Worafi

~~185,50€~~ 166,95€ 10% OFF

 Addresses the need for pharmacists to have diverse skills. Covers cardiovascular care; abdomen/gastrointestinal tract care; musculoskeletal system care; skin care; head, eyes, ears, nose, and throat care; chest/lung care; genitourinary system care; neurological system care; renal care; endocrine care; psychiatric care; hematological care;
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Handbook Of Evidence-Based Pharmacist Care: Clinical, Economic, And Humanistic Impacts - Volume 11: Pharmacist Care In Special Services

by Yaser Mohammed Al-Worafi

~~185,50€~~ 166,95€ 10% OFF

 Showcases the expanded roles and responsibilities of pharmacists in specialized services. Key topics: antibiotics, weight management, smoking cessation, medication therapy management, health education and promotion, medication compliance, OTC and nutraceuticals, patient safety, self-care, etc.
ENGLISH

Natural Products In Drug Discovery - Benefits, Challenges, And Opportunities

~~278,25€~~ 250,43€ 10% OFF

 Combines traditional medicine with modern techniques for using products derived from natural sources for drug development. Presents information on bioactive potential of natural products with antimicrobial, immunomodulatory, anti-cancerous, anti-inflammatory, hepatoprotective, antiviral, etc. properties and their use in drug development.
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Power Dynamics In The Pharmaceutical Industry. A Case Study Of Astrazeneca

by Afshan Yasir

~~7,78€~~ 7,00€ 10% OFF

 Case Study from the year 2023 in the subject Medicine - Pharmacology, Pharmacy, grade: A, University of Balochistan (Institute of Biochemistry), course: Biotech, language: English, abstract: This case study delves into the complex power dynamics within AstraZeneca, one of the most influential pharmaceutical corporations globally. It explores how the company wields power within the healthcare industry, impacting health improvements, lifestyle changes, and stakeholder interactions. The analysis focuses on AstraZeneca's internal structure, sources of power, key stakeholder relationships, and the regulatory framework that governs its activities. By examining the intricate nature of power within the organization, this study provides insights into how AstraZeneca navigates its prominent role in the pharmaceutical sector and the broader implications of its influence.
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Barriers Regulatory Agencies Face For Approval Of Parkinson'S And Alzheimer'S Drugs In United States And Europe, And Possible Ways To Overcome Them

by Kunal Kunal

~~21,97€~~ 19,77€ 10% OFF

 Master's Thesis from the year 2023 in the subject Medicine - Pharmacology, Pharmacy, grade: A, , language: English, abstract: There are many challenges in developing effective treatments for neurodegenerative diseases like Parkinson's and Alzheimer's. Regulatory agencies in the US and EU play a significant role in determining the efficacy and safety of drugs used to treat these conditions. However, the approval process is convoluted and frequently encounters obstacles that delay timely access to critically needed treatments. This thesis seeks to identify, examine, and suggest potential remedies for the problems regulatory bodies in both regions encounter. Through an extensive review of the literature, regulatory standards, and case studies, the thesis looks at the major challenges encountered throughout the drug approval process for Parkinson's and Alzheimer's diseases. Scientific roadblocks including the complexity of disease mechanisms and the lack of knowledge of sickness progression make it difficult to show therapy efficacy and choose the appropriate patient populations. Clinical issues arise from the diversity of the patient population, the dearth of reliable biomarkers, and the need for precise long-term data for therapy benefit assessment. Regulatory impediments are procedures and rules that differ between the US and Europe. These include changes to regulatory structures, clinical trial designs, and data requirements. Regulatory standards must be standardised, regulatory authorities must collaborate more closely, and data requirements must be uniform to expedite the clearance process and guarantee universal access to medications. The thesis offers various strategies that regulatory agencies, pharmaceutical companies, and researchers can use to get around these challenges. Greater stakeholder collaboration and data sharing can promote the pooling of knowledge and resources, which will lead to more thorough clinical research and better outcomes. Adaptive trial designs and master protocols are examples of cutting-edge trial designs that can aid in patient recruitment and data collection. Utilising patient registries and actual data can speed up the approval procedure and provide more information about the results of treatment. To align expectations and proactively resolve regulatory concerns, early communication between regulatory organisations and drug developers is crucial. [...]
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Green Synthesis Of Silver Nanoparticles And Its Method Development And Validation By Uv Spectroscopy In Bulk Pharmaceuticals

by U. M. Patel

~~17,82€~~ 16,04€ 10% OFF

 Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, grade: 9.5, , language: English, abstract: In this study, we report the synthesis of Ag NPs by green synthesis process using Datura metel leaf extract as reducing agent. The final products characteristics were studied - optical, structural, surface morphology and elemental analysis. Silver Nanoparticle has been recognized as a safe inorganic, antibacterial, nontoxic agent. Conventional synthesis of Silver Nanoparticle can generate toxic waste during the reaction process hence, this paper the green synthesis approach used and for synthesis of silver nanoparticle by using Datura metel leaf extract as a reducing agent. The change in colour of silver nitrate solution from colourless to brown was visual identification for formation of Silver Nanoparticle and shown the absorption at 447 nm. The synthesized Silver Nanoparticle were of size 180 nm analyse by SEM and further characetrised by FTIR where carboxylic peak was obtained at 1675 cm-1 as well as presence of alcoholic group and polyphenols. Further validated method was developed and linearity was found to be 0.995 and % RSD of validation parameters were found to be within the limit <2%. A simple, lab scale, rapid, accurate, precised and sensitive spectroscopic method has been developed and validated as per ICH guideline for synthesized silver nanoparticle in bulk pharmaceuticals by UV vis spectrophotoscopy and which is applicable for routine analysis.
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Development And Validation Of Differential Spectrophotometric Method For Assay Of Enrofloxacin In Bulk And Tablet Formulation

by M. Patel

~~15,58€~~ 14,02€ 10% OFF

 Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, , course: M pharmacy, language: English, abstract: A simple, precise and accurate spectrophotometric method have been developed and validated for the estimation of Enrofloxacin in bulk as well as tablet formulation. The UV spectra of Enrofloxacin was obtained in 0.1N HCl and 0.1N NaOH, and the overlain spectra showed maximum absorbance at 271.0 nm (maxima) and 276.5 nm (minima) in 0.1N NaOH and HCl respectively. The drug follows linearity in the range of 5-30 ug/ml (R2= 0.988). Both intra- and inter-day precision showed % RSD? 2 while LOD and LOQ were 0.320 and 0.971 respectively. The method was validated as per ICH guidelines. Enrofloxacin or [1-cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3 quinoline carboxylic acid]. The chemical structure of the drug is given in. It is a synthetic antibacterial agent from the class of the fluroquinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria. Enrofloxacin is used for the treatment of individual pets and domestic animals. Literature survey shows that several analytical methods for the determination of Enrofloxacin include RP-HPLC, HPLC, RP-LC, LC and dissolution study have been reported. Many pharmaceutical products have been assayed by this method. But Differential UV spectrophotometric method of Enrofloxacin was not reported as so far. So an attempt was made to develop a novel, simple, accurate spectrophotometric method for the determination of Enrofloxacin in tablet formulation.
ENGLISH

Formulation, Development And Textural Characterization Of Nano-Engineering Strategy Assisted Topical Antifungal Nanolipogel

by Unnati Patel

17,90€ + 10% CARD

 Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, grade: 9.5, , language: English, abstract: The aim of the present research work was to formulate, develop and characterize topical antifungal nanolipogel using hundred-times-washed cow ghee base known as shatadhautaghrita. It is used as a permeation enhancer to increase the permeation rate of fluconazole. Nine formulations of nanolipogel were prepared using different concentrations of carbopol and shatadhautaghrita. The optimized batch of nanolipogel (formulation F7) was evaluated for pH, percentage yield, drug content, extrudability, rheology. The consistency, spreadability and formation of nanosize particles were assessed through texture profile analysis and zetasizer. Fluconazole (FLZ) is an antifungal agent used mainly in topical formulations to treat various skin disorders such as oropharyngeal candidiasis, cryptoccocal meningitis and cutaneous dermatophyte infections. FLZ is a synthetic triazole derivative that acts as an antifungal. FLZ preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation. Shatadhautaghrita(SDG) is used as a natural permeation enhancer in topical products. It is prepared by washing cow ghee 100 times with water.shatadhautaghrita is (shata = one hundred, dhauta = washed) clarified butter fat that has been washed 100 times. The use of shatadhautaghrita in managing conditions such as burns, chicken pox, scars, wounds, herpes, leprosy and other skin diseases and as a vehicle for drugs for external application are mentioned in traditional texts. The characteristic odour and granular, oily consistency of cow ghee are not present in shatadhautaghrita, and so it is a homogeneous, smooth, non-oily product that is easier to apply. The neutral pH of shatadhautaghrita compared with the acidic pH value of ghee makes shatadhautaghrita beneficial by preventing skin irritation. The reduced particle size of shatadhautaghrita makes the product non-granular, non-sticky and homogeneous, which makes it easy to apply it on the skin and may result in an increased rate of absorption through the skin. Washing results in a homogeneous oil-in-water emulsion with better consistency and viscosity, which makes it suitable for use in topical applications.
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Ocular Drug Delivery Systems

by Manish Kumar

18,55€ + 10% CARD

 Academic Paper from the year 2023 in the subject Medicine - Pharmacology, Pharmacy, , course: M.Pharmacy, language: English, abstract: Ocular drug delivery plays a vital role in the treatment of various eye diseases and conditions. The unique anatomical and physiological characteristics of the eye pose significant challenges for effective drug delivery. Over the years, extensive research efforts have been dedicated to developing innovative strategies and formulations to overcome these challenges and improve therapeutic outcomes. This review provides an overview of recent advances in ocular drug delivery, highlighting the key challenges faced and discussing the potential future directions in this field. The first section of the review focuses on the barriers to ocular drug delivery, including the tear film, cornea, conjunctiva, and blood-ocular barriers. These barriers limit the bioavailability and efficacy of drugs administered to the eye. Strategies to bypass or overcome these barriers, such as the use of penetration enhancers, nanoparticles, and prodrug approaches, are discussed. The second section explores various ocular drug delivery systems, including eye drops, ophthalmic gels, ocular inserts, and contact lens-based delivery systems. Each system is examined in terms of its advantages, limitations, and recent advancements. Special attention is given to sustained drug release systems that aim to prolong drug residence time on the ocular surface and improve patient compliance. Next, the review delves into the role of nanotechnology in ocular drug delivery. Nanoparticles, liposomes, and nanomicelles have shown promise in improving drug solubility, stability, and ocular bioavailability. The use of novel nanomaterials and their surface modifications for targeted drug delivery to specific ocular tissues is also discussed. Furthermore, the review highlights emerging techniques in ocular drug delivery, such as microneedles, hydrogels, and gene therapy-based approaches. These technologies offer exciting prospects for precise and personalized treatment of ocular diseases. Finally, the review concludes by discussing the regulatory considerations, safety aspects, and clinical translation of ocular drug delivery systems. The importance of collaboration between researchers, clinicians, and regulatory bodies in advancing this field is emphasized.
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Comparative Analysis Of The Physicochemical And Release Properties Of Amoxicillin Trihydrate Tablets Formulated With Different Types Of Binders

by Peter Ugwu Akor

44,81€ + 10% CARD

 Academic Paper from the year 2022 in the subject Medicine - Pharmacology, Pharmacy, grade: 97.7, , course: Pharmaceutical Technology, language: English, abstract: The aim of this research is to compare the physicochemical and release properties of amoxicillin trihydrate tablets 500mg using different binder (Peptin powder B.P, Microcrystalline cellulose and Corn starch mucilage at different concentration of 5%, 7.5%, 10% and 12.5%) to evaluate the hardness, thickness, tensile strength, weight uniformity, friability, disintegration time, dissolution rate/absorbance, moisture content and FTIR . It was revealed from the result of the study that the angle of repose varied from 30.2 2.96 to 27.2 1.2. This shows that the granules had good flow property as they were below 30o which indicates the granules is free flowing. The bulk density was found to be in the range of 0.56 0.05 to 0.54 0.056. As the granule size increases, bulk density decreases. The tapped density range from 0.65 0.06 to 0.65 0.06 while compressibility index was between 17.41 12.6 to 8.92 3.61. This was less than 10% indicated in the British Pharmacopeia from excellent flow character. This indicates that the granules had excellent flow character. The Housners ratio ranged from 0.825 0.09 to 0.92 0.035 for the different batches. The batches within 1.00 - 1.11 range had excellent flow character while the batches within the range of 0.83-0.825 had good flow character but not as the other batches. The physiochemical evaluations of the amoxicillin granules showed good flow character. All the sample passes friability test with range of 1.0 above except for two sample (corn starch mucilage 5%w/w and 5% microcrystalline cellulose that fall below 1.0%). Uniformity in tablet diameter depends on diameter of the punch use for the compression process the standard deviation permitted is 5% of the mean diameter (British Pharmacopoeia). To this regard all the tablet passed the test by corresponding to stated standard with the range of 0.57g-0.58g. The standard binder efficiency is <30% to achieve good granule friability, however, the results for all sample shows below 30% this indicate good binding potential in pharmaceutical formulations. For hardness test, they was an increase in values as the concentration increases with the range (CSM 3.96 - 5.5, PTN 2.67 to 4.0 and MCC 3.9 to 4.9) kg respectively.
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Chagas Disease. Discovery Of A Tcglck Inhibitor Through Lead Optimisation Of Cbz-Glcn

by Maciej Nodzynski

15,69€ + 10% CARD

 Seminar paper from the year 2023 in the subject Medicine - Pharmacology, Pharmacy, grade: A+, Utrecht University, course: Medicinal Chemistry, language: English, abstract: Chagas disease, also known as American trypanosomiasis, is a neglected tropical disease that poses a serious threat to public health in South and Central America, but not only there. The disease affects large groups of people in underdeveloped areas, causing around 12,000 deaths every year. There is no effective treatment for the chronic phase of the disease, while the drug-resistant strains of the Trypanosoma cruzi parasite start challenging the usefulness of the acute phase treatment. Consequently, new drug candidates need to be developed. This paper proposes a novel drug candidate that was created by optimising the lead molecule called CBZ-GlcN. The affinity of the reported drug candidate is exceptional (Kdiss = 7.11 nM), showing a 890-fold improvement over the affinity of CBZ-GlcN for TcGlcK. Furthermore, the new molecule exhibits advantageous pharmacokinetic properties. The paper also reports a suggested synthesis route for the drug candidate, which can be used to perform in vivo tests examining properties such as affinity, specificity, and toxicity of the drug candidate.
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Regulatory Guidelines For Registration And Submission Criteria In South Africa (Sahpra)

by G. Snehalatha, N. S. R. L. Manimala e Shailaja Pashikanti

41,64€ + 10% CARD

 Document from the year 2022 in the subject Pharmacology, Andhra University (A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam), course: Pharmaceutical Regulatory Affairs, language: English, abstract: This publication examines the regulatory guidelines for registration and submission criteria in South Africa. South African Health Products Regulatory Authority (SAHPRA) is the entity of the national department of health (NDoH) launched in February 2017. It replaced the former Medicines Control Council (MCC) as well as Directorate of Radiation Control (DRC) that regulated medical devices in-vitro diagnostic tests and devices, radiation-emitting products and devices used in health care and industry. Due to several drawbacks of MCC such as becoming dependent on external expertise, it eventually lead to lack of effective performance management contracts and unsustainable mechanism for submission of evaluation reports, SAHPRA is established. An application for registration of medicines should be submitted for evaluation and approval through SAHPRA guidelines which are applicable to human medicines including biological and complimentary medicines. So SAHPRA adopted EU variation guidelines for quality and bio equivalence requirements for new registration and variations that are submitted by applicant in eCTD format established by the International Council for Harmonization (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use. Submission of applications are done by following South Africa eCTD validation criteria in module 1 of regional information provided by South Africa.
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Anti-Helminthic And Pesticidal Effect Of Heliotropium Indicum Linn. Pharmacology Of Natural Products

by Asamoah Larbi

1,31€ + 10% CARD

 Bachelor Thesis from the year 2013 in the subject Medicine - Pharmacology, Pharmacy, grade: A, , course: Department of Laboratory Technology, language: English, abstract: Imagine a world where traditional remedies hold the key to combating parasitic infections and agricultural pests, offering a sustainable alternative to synthetic chemicals. This groundbreaking research delves into the untapped potential of Heliotropium indicum Linn, a plant revered in herbal medicine, to unearth its potent anti-helminthic and insecticidal properties. Through rigorous scientific investigation, this study unveils the efficacy of aqueous extracts derived from the plant's inflorescences, leaves, and roots against intestinal helminths and the destructive weevil species, Sitophilus zeamais. Explore the comparative effectiveness of extracts from different plant parts, revealing nature's intricate design for defense. Uncover the secrets of the plant's phytochemical composition through comprehensive screening, identifying the key secondary metabolites responsible for its biological activity. Delve into the correlation between these natural compounds and their impact on parasite paralysis and mortality, paving the way for innovative and eco-friendly solutions. This vital work not only validates traditional knowledge but also provides a scientific foundation for the development of novel treatments for worm infections and sustainable pest control strategies, offering a beacon of hope for improved health and agricultural practices. The findings presented here contribute significantly to the growing body of knowledge on herbal medicine and its potential to address pressing global challenges, making it an invaluable resource for researchers, practitioners, and anyone seeking natural alternatives for health and agriculture. Discover the power of Heliotropium indicum Linn and its role in shaping a healthier and more sustainable future, one extract at a time, offering new avenues for combating parasitic diseases and protecting vital food resources. This research illuminates the path towards harnessing nature's pharmacy for the benefit of humanity, providing a compelling case for further exploration of plant-based solutions for a wide range of health and agricultural challenges, underscoring the importance of preserving biodiversity and traditional ecological knowledge.
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