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Mass Spectrometry - An Applied Approach

131,11€ + 10% CARD

 Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. <ul> <li>Provides a description of mass spectrometry basics, applications and perspectives of the technique</li> <li>Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field</li> <li>Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation</li> <li>Includes a list of key terms, and test questions, for easier and faster understanding of the material </li> </ul> Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.
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Integration Of Omics Approaches And Systems Biology For Clinical Applications

205,42€ + 10% CARD

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 Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine.
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Integration Of Omics Approaches And Systems Biology For Clinical Applications

201,33€ + 10% CARD

 Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.
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Mass Spectrometry And Stable Isotopes In Nutritional And Pediatric Research

185,43€ + 10% CARD

 A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders, and Kidney Disorders Focuses on the interactions between nutrients and the endogenous metabolism within the body and how these factors affect the health of a growing infant
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Interpretation Of Ms-Ms Mass Spectra Of Drugs And Pesticides

by Ricardo A. Correa C. e Wilfried M. A. Niessen

148,33€ + 10% CARD

 Provides comprehensive coverage of the interpretation of LC MS MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
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Chemical Analysis Of Non-Antimicrobial Veterinary Drug Residues In Food

222,53€ + 10% CARD

 Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food <ul> <li>Provides a comprehensive set of information in the area of consumer food safety and international trade</li> <li>Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods</li> <li>Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs</li> <li>Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists</li> </ul>
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Analysis Of Protein Post-Translational Modifications By Mass Spectrometry

by John R. Griffiths e Richard D. Unwin

147,01€ + 10% CARD

 <ul> <li>Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation</li> <li>Discussion of the chemistry behind each modification, along with key methods and references</li> <li>Contributions from some of the leading researchers in the field</li> <li>A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research</li> </ul>
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Protein Carbonylation - Principles, Analysis, And Biological Implications

205,42€ + 10% CARD

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 Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman s lab at NIH started in early 1980s.
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Lipidomics - Comprehensive Mass Spectrometry Of Lipids

by Xianlin Han

165,56€ + 10% CARD

 Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes
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Mass Spectrometry For The Analysis Of Pesticide Residues And Their Metabolites

by Anastasios Economou, Despina Tsipi e Helen Botitsi

141,71€ + 10% CARD

 Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites.
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Cluster Secondary Ion Mass Spectrometry - Principles And Applications

by Christine M. Mahoney

141,71€ + 10% CARD

 Explores the impact of the latest breakthroughs in cluster SIMS technology Cluster secondary ion mass spectrometry (SIMS) is a high spatial resolution imaging mass spectrometry technique, which can be used to characterize the three-dimensional chemical structure in complex organic and molecular systems. It works by using a cluster ion source to sputter desorb material from a solid sample surface. Prior to the advent of the cluster source, SIMS was severely limited in its ability to characterize soft samples as a result of damage from the atomic source. Molecular samples were essentially destroyed during analysis, limiting the method's sensitivity and precluding compositional depth profiling. The use of new and emerging cluster ion beam technologies has all but eliminated these limitations, enabling researchers to enter into new fields once considered unattainable by the SIMS method. With contributions from leading mass spectrometry researchers around the world, Cluster Secondary Ion Mass Spectrometry: Principles and Applications describes the latest breakthroughs in instrumentation, and addresses best practices in cluster SIMS analysis. It serves as a compendium of knowledge on organic and polymeric surface and in-depth characterization using cluster ion beams. It covers topics ranging from the fundamentals and theory of cluster SIMS, to the important chemistries behind the success of the technique, as well as the wide-ranging applications of the technology. Examples of subjects covered include: Cluster SIMS theory and modeling Cluster ion source types and performance expectations Cluster ion beams for surface analysis experiments Molecular depth profiling and 3-D analysis with cluster ion beams Specialty applications ranging from biological samples analysis to semiconductors/metals analysis Future challenges and prospects for cluster SIMS This book is intended to benefit any scientist, ranging from beginning to advanced in level, with plenty of figures to help better understand complex concepts and processes. In addition, each chapter ends with a detailed reference set to the primary literature, facilitating further research into individual topics where desired. Cluster Secondary Ion Mass Spectrometry: Principles and Applications is a must-have read for any researcher in the surface analysis and/or imaging mass spectrometry fields.
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Mass Spectrometry For Drug Discovery And Drug Development

150,98€ + 10% CARD

 Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
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Uremic Toxins

by Toshimitsu Niwa

153,63€ + 10% CARD

 With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices.
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Cluster Secondary Ion Mass Spectrometry - Principles And Applications

by Christine M. Mahoney

144,59€ + 10% CARD

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 This book describes the importance of the emerging technique Cluster Secondary Ion Mass Spectrometry (SIMS), which is used for the analysis of a range of solid materials, including everything from organic and polymeric materials, to cells and semiconductors.
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Mass Spectrometry For Drug Discovery And Drug Development

154,05€ + 10% CARD

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 With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists.
ENGLISH

Uremic Toxins

by Toshimitsu Niwa

152,70€ + 10% CARD

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 With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices.
ENGLISH

Mass Spectrometry In Sports Drug Testing - Characterization Of Prohibited Substances And Doping Control Analytical Assays

by Mario (German Sport University, Cologne, Germany) Thevis

143,23€ + 10% CARD

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 * Mass Spectrometry is a major tool to characterize, identify and detect hundreds of known and unknown drugs.
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Mass Spectrometry Of Non-Covalent Complexes - Supramolecular Chemistry In The Gas Phase

by Andreas Springer e Christoph A. Schalley

189,20€ + 10% CARD

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 Resolves points of error and misinterpretation that have plagued the use of mass spectrometry in supramolecular chemistry. Provides a brief introduction to mass spectrometry and supramolecular chemistry in order to orient the audience. Offers supramolecular chemists a detailed introduction to mass spectrometric methodology.
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Chemical Analysis Of Antibiotic Residues In Food

148,64€ + 10% CARD

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 * Provides a single source for readers interested in the development of analytical methods to measure antibiotic residues in food. * Topics include general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods.
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Illicit Drugs In The Environment - Occurrence, Analysis, And Fate Using Mass Spectrometry

121,60€ + 10% CARD

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 Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis.
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Comprehensive Chromatography In Combination With Mass Spectrometry

160,81€ + 10% CARD

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 * Comprehensive chromatography represents one of the most powerful tools in the separation of complex mixtures * The book is both broad covering many areas of techniques and applications while still being focused to a specific topic.
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Redox Proteomics - From Protein Modifications To Cellular Dysfunction And Diseases

283,83€ + 10% CARD

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 Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases.
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Cancer Biomarkers - Analytical Techniques For Discovery

by Mahmoud H. (Glaxosmithkline, Italy) Hamdan

179,73€ + 10% CARD

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 Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers.
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Proteomic Biology Using Lc/Ms - Large Scale Analysis Of Cellular Dynamics And Function

by Dominic M. Desiderio, Nico M. Nibbering, Nobuhiro Takahashi e Toshiaki Isobe

136,47€ + 10% CARD

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 One of the primary goals of current proteomic research is the description of the composition, dynamics, and connections of the multi-protein "modules" and "machineries" that perform a wide range of biological functions in the cell. This is one of the first books to focus on the dynamic aspect of proteomes.
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