Resultados de Pesquisa

INGLÊS

Regulation Of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation Of Protein Phosphorylation Calcium-Activated Neutral Protease Microb

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 Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents.
INGLÊS

Essential And Non-Essential Metals Metabolites With Antibiotic Activity Pharmacology Of Benzodiazepines Interferon Gamma Research

158,34€ + 10% EM CARTÃO

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 Scientific progress, more and more, makes it possible to relate disease to irreg- ularities on a molecular basis. Werner (FRG) . . . . . . . . . . . . . . . . . . . . . . . 47 . . . . .
INGLÊS

Oncogenes And Human Cancer Blood Groups In Cancer Copper And Inflammation Human Insulin

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 l Tumor transformation produces numerous antigenic alterations ), particularly 2 among the glycoconjugates, sugars linked to each other, to lipids and to proteins , 3). Many blood group antigens are identified as glycoconjugates; they include the 4 ABO(H) , MNT, Lewis, Ii and P antigens ). These determinants are particularly valuable since they can be understood in terms of their serology, chemical structure and biochemical genetics4-7). Their specific functions are not well understood; how ever, their position as terminal or penultimate sugars may assign them a special role lO as protective or informational moleculesS- ). Ordinarily, these antigens, equally 4lO described on erythrocytes ), persist unchanged throughout the lifetime of the indi vidual, but they may be susceptible to alterations in the presence of certain hematopoietic diseases and solid tissue tumors, primarily carcinomas. A review of 11 this topic was published by one of us in 1980 ). New data has accumulated rapidly since then, particularly in the areas of structural analysis, biochemical genetics, and immunologic and tumor marker relationships. The purpose of this review is to provide an update of progress realized in these areas. Other reviews with emphasis 12 l5 on special areas are also available - ). Current and prospective experimental studies should be of use in regard to the following questions: 1.
INGLÊS

Metabolic Control In Diabetes Mellitus Beta Adrenoceptor Blocking Drugs Nmr Analysis Of Cancer Cells Immunoassay In The Clinical Laboratory Cyclospori

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 The close association between blood glucose control and the well-being of the patient, as well as the risk for the development of the "late" complications of 3 diabetes, make it necessary to attain near normalisation of blood glucosel- ). Signifi cant progress has been made in this direction in the last few years because of the advancement of analytical techniques for the monitoring of both metabolic status and the functional state of the pancreas and the kidneys, organs involved in the disease process. The respective methodologies are the test strips for self-monitoring of glucose in blood and urine, the measurement of the nonenzymatic glycosylation of hemoglobin and serum proteins, the C-peptide assay, and the determination of small amounts of albumin in urine. The test strip methodology for determination of glucose in blood and urine has made possible home blood glucose monitoring which enables the patient to aim for treatment targets near the physiological range. To this information on short term glycemia obtained by the patient, the determination of hemoglobin glycosylation in the clinical chemistry laboratory adds quantitative information about averaged long term glycemic control. The C-peptide assay allows evaluation of the residual pancreatic function in the presence of exogenous insulin. Results of a C-peptide assay are helpful in selecting the appropriate treatment for poorly controlled maturity-onset diabetes. The detection of microalbuminuria, an abnormal albumin excretion below the level of "Albustix" detection, establishes nephropathy before renal damage becomes irreversible.
INGLÊS

Emergence Of Drugs Which Block Calcium Entry

de John R. Regan, Peter S. Wolf, Ronald D. Smith e Stanley R. Jolly

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 Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
INGLÊS

Clinical Biochemistry In Hepatobiliary Diseases - Proceedings Of The International Satellite Symposium, Bologna, Italy, 1988

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 The clinical biochemistry ofhepatobiliary diseases is very widely studied, and publica tions abound on this topic. However, there is no recent publication that provides a comprehensive collection of the various leading aspects that go to make up this complex theme. Therefore, we thought it useful to gather together a few scientists whose work has focused on the various clinical biochemistry-aspects of these disorders in order that they might discuss their experience and expertise. The aim of the International Satellite Symposium on Clinical Biochemistry in Hepatobiliary Disease, in addition to reviewing the individual aspects, was to describe the state-of-the-art so as to provide useful data for laboratory scientists and also for physicians working in the field of hepatobiliary diseases, and these two aims are clearly reflected in the chapters of this volume. The volume opens with an introductory chapter that gives a general overview of the various aspects of the clinical biochemistry of these disorders, while the closing chapter deals with an important aspect that deserves to be increasingly emphasized in laboratory medicine, i.e., strategies to integrate information coming from the laboratory to make them more useful for clinical diagnosis.
INGLÊS

Ruthenium And Other Non-Platinum Metal Complexes In Cancer Chemotherapy

de Donald T. Forman, Etienne Baulieu, James L. Wittliff, John A. Kellen, Liane Will-Shahab, Lothar Jaenicke, Lothar Trager, Magnus Ingelman-Sundberg e Yashitaka Nagai

171,59€ + 10% EM CARTÃO

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 With contributions by numerous experts
INGLÊS

Immobilized Enzymes In Medicine

de Vladimir P. Torchilin

171,59€ + 10% EM CARTÃO

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 The application of immobilized enzymes in medicine is the main objective of this book. The author reviews natural and synthetic carriers for enzyme immobilization, chemistry of enzyme binding, and in-vitro and in-vivo properties of immobilized enzymes. Four chapters are dedicated to clinical use of immobilized enzymes.
INGLÊS

Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators

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INGLÊS

Calcitonins - Physiological And Pharmacological Aspects. Mafosfamide - A Derivative Of 4-Hydroxycyclophosphamide. Enzymatic Dna Methylation

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