Resultados de Pesquisa

INGLÊS

Understanding Biotransformation

~~108,65€~~ 97,79€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 This book provides the basic concepts of biotransformation and its applications in the fields of pharmaceutical and food industries, as well as in drug development. It offers alternative solutions to conventional methods of chemical synthesis by providing examples that directly contribute to saving time, reducing costs, and providing the public safety necessary in drug manufacturing and development. This book explores how biological catalysts work to carry out reactions on natural and pharmaceutical compounds in single steps with high regio- and stereospecificity. The book also provides useful results that, in turn, lead to developments in the pharmaceutical and food industries.This book also establishes the principles of using sustainable green chemistry, which reduces the use of dangerous chemicals by workers and researchers.
INGLÊS

Lipases And Their Role In Health And Disease

~~125,88€~~ 113,29€ 10% IMEDIATO

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 This comprehensive work illuminates the molecular foundations and applications of lipases, offering an understanding of their significance in human well-being as well as diseases. Chapter one begins with the meticulous exploration of lipase biochemistry. Chapter two delivers a move beyond digestion to explore the health benefits, metabolic influences, and therapeutic potential of lipases. Chapter three addresses the global issue of obesity. Readers gain insights into the diverse applications and sustainability of lipases, breaking down triacylglycerols in various industries. Probiotic isolates are explored for their role in preventing oxidative rancidity, improving shelf life, and serving as industrial biocatalysts in diverse bioconversion reactions. In Chapter four, the authors present an eco-friendly approach to surfactant synthesis, showcasing the environmental advantages over chemical counterparts. Chapter five delves into the multifaceted roles of lipases. In the last chapter the ubiquitous nature of lipases is underscored. These enzymes, produced by all living organisms, play crucial roles in digestion, transport, and processing of dietary lipids. This chapter navigates through the ubiquity of cellular enzyme lipases in diseased conditions in human, animals and birds and its adverse impact. This book transcends the boundaries of conventional enzymatic literature. This pioneering work promises readers a holistic view of lipase biology, offering a profound understanding of their intricate mechanisms and multifaceted roles in health and disease.
INGLÊS

Properties And Uses Of Oleanolic Acid

~~125,88€~~ 113,29€ 10% IMEDIATO

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 Cancer is a leading cause of death worldwide. In 2018, 9.6 million deaths were attributed to cancer, and it is affecting around 18 million patients each year. Natural products have been considered as the major source of lead compounds for cancer treatment. A large number of natural products have been reported by researchers all over the world and many of them are in clinical trials. In recent years, there has been a growing interest in pentacyclic triterpenoids such as Oleanolic acid, -boswellic acid, ursolic acid, betulinic acid, glycyrrhetinic acid and maslinic acid as potential anticancer agents reflected by the exponential increase in the number of scientific publications and patents published on these natural products all over the world. Moreover, some of these pentacyclic triterpenoids have already been marketed in some countries as therapeutic agents for the treatment of several disorders such as cancer, diabetes, inflammation, liver disorders, etc. Two major derivatives of oleanolic acid, CDDO and CDDO-Me, have been entered into clinical trials against cancer. This book highlights the potential of oleanolic acid and its derivatives in the treatment of several human disorders. Initial chapters discuss the sources, extraction, biosynthesis and various reported biological activities of oleanolic acid while subsequent chapters describe the in vitro and in vivo applications of oleanolic acid and its different derivatives in several diseases such as bacterial infections, breast cancer, colon cancer and hepatic disorders. The last chapter of the book describes the nanoparticle-mediated delivery of oleanolic acid in cancer.
INGLÊS

Chemistry Of Nitriles

~~125,88€~~ 113,29€ 10% IMEDIATO

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 The book "Chemistry of Nitriles" provides relevant and updated information about the unique class of compounds called nitriles. The presence of cyano groups characterizes nitriles and is of great significance in diverse industrial processes. This book encompasses seven chapters presenting a critical perspective of nitriles involving chemical and biological aspects. Various chemical, industrial, and biological processes have shown the involvement of nitrile compounds as key intermediate compounds. Microorganisms can metabolize these compounds through various metabolic processes involving diverse enzyme systems. The role of these compounds in biotechnological advancements has been elaborated in various chapters. The enzymes discussed in this book include nitrilase, nitrile hydratase, amidase, and aldoxime dehydratases. Bioprocess development and novel immobilization strategies with immense commercial potential have been discussed threadbare in this book. Hence, this book will be of great value for budding microbiologists and biotechnologists to obtain updated information on incorporating new and innovative technologies in research and development. Furthermore, chemists and pharmaceutical scientists will also target readers of this book. The reaction mechanisms and chemical transformation experimentations have revealed the fascinating world of chemistry involving nitrile compounds. This book will be a treat for science enthusiasts interested in interdisciplinary research and the significant role of nitriles in the interdependency of chemistry and biology, thus serving as a platform for future novel research and outcomes.
INGLÊS

Biochemical Guide To Toxins

~~304,75€~~ 274,28€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 This book aims to provide scientific information about toxins. Toxins are chemicals produced by living organisms that are poisonous to another organism. The chapters present the characteristics of toxins that can be harmful to tissues, organs or biological processes of living organisms, produced only by other living organisms. The authors of the prepared chapters also present the most popular toxins.
INGLÊS

Airborne And Biological Monitoring To Assess Occupational Exposure To Isocyanates

de Jimmy Hu

125,88€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This comprehensive guide is an essential resource for professionals working in industries that use isocyanates in the manufacturing of polyurethanes, foams, coatings, adhesives, and other materials. It provides a thorough understanding of the potential health hazards posed by isocyanates and offers practical insights into reducing occupational exposure to these compounds through effective airborne and biological monitoring techniques. The book covers the latest policies and occupational exposure standards for isocyanates, making it relevant for an international audience. It also highlights the rapid advances in analytical methods and new technologies, including modern analytical methods used to quantify isocyanate derivatives from both airborne and biological monitoring. The guide focuses on the latest developments in airborne monitoring methods, including those evaluated based on the latest peer-reviewed journal papers. Additionally, it provides the first substantial review of biological monitoring exposure to isocyanates in the workplace. The book delves into the analytical methods used for better efficiency and quick turn-around, the efficacy of exposure controls, and quality assurance programs used. This accessible guide will be useful to occupational hygienists, analytical chemists, laboratory chemists, researchers, students, and anyone seeking to manage the risks of isocyanates in the workplace. It covers a range of topics, from exposure routes and risk management to exposure controls, sampling, and laboratory analytical methods. The book concludes with a summary of future work required in the field, research priorities, and predictions of long-term research goals for both airborne and biological monitoring of occupational exposure to isocyanates. Overall, this is an indispensable reference for anyone involved in managing isocyanate risks in the workplace.
INGLÊS

Medical Biology Guide To Proteins

108,65€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book aims to provide scientific information about proteins. 28 chapters have been written that describe the characteristics of proteins and their influence on human physiology. The authors presented the structure of individual proteins and their role in particular diseases. Proteins are among the most important nutrients responsible for the proper functioning of the body. Protein is one of the basic building blocks of our tissues and plays a role in transport, regulating biochemical processes and in reactions initiated by the immune system.
INGLÊS

Water In Biology: A Molecular View

de Michael E. Green

258,38€ + 10% EM CARTÃO

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 Water is well known to be an essential component of all biological systems. Thousands of papers describe a role for water interacting with ions, proteins, nucleic acids, and lipids. In this book, the authors discuss the background chemistry and physics, including a very brief review of thermodynamics and quantum mechanics, to the limited extent needed for the remainder of the book. The various behaviors of water at surfaces, in solutions, in hydrating ions, proton transport, as well as the phase changes that involve water, are introduced. Hydrogen bonds, their networks, and the way they are associated with proteins are discussed, along with proton transport, which is important in a number of biological systems. The authors then proceed to discuss water in confined spaces, and in channels and transporters, which are topics particularly important in biology. Some special topics are interesting, like anhydrobiosis, and those are touched upon briefly. The authors have made no attempt to make this book comprehensive; the thousands of papers that have been published that are relevant provide far too much material for a single volume. Enough material is presented so that the reader sees what is now known, or at least is thought to be known. As with any science, sometimes we are pretty sure of something, only to find ground shifting under us as new experimental results show that what we thought we knew, we didn’t. However, a snapshot of the present state of knowledge is useful. Knowledge is progressing so rapidly that at least some will need updating as this is being written, but this is a good time to summarize what is currently known, and provide background information that will help understand what is coming.
INGLÊS

Biochemical Guide To Proteins

125,88€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book aims to provide scientific information about proteins. 30 chapters have been written that describe the characteristics of proteins and their influence on human physiology. The authors presented the structure of individual proteins and their role in particular diseases. Proteins are among the most important nutrients responsible for the proper functioning of the body. Protein is one of the basic building blocks of our tissues, plays a role in transport, regulating biochemical processes and in reactions initiated by the immune system.
INGLÊS

Biomolecules And Corrosion

de Santosh Kumar Karn

125,88€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Corrosion causes great losses to the economy every year. Microbial-influenced corrosion (MIC) is important for maritime, chemical engineering, and bioprocess engineering industries. Presently no environmentally friendly technology has been available to minimize the economic loss of biocorrosion. Currently available anti-biocorrosion technology depends heavily on chemical methods to regulate biofilm formation which has a negative impact on the environment. Therefore, it is essential to know the fundamentals of the roles of biomolecules within the whole process to develop detailed research capabilities and potential control and management strategies. This book targets the roles of EPS, proteins, lipids, DNA, and different metabolites currently known to be involved in the corrosion processes. The potential roles of EPS, proteins, lipids and enzymes are still poorly understood. There are still collective issues that need to be addressed, including the importance of the microbial role in MIC. More specifically, there exists a need to understand the impact of enzyme activities inside the biofilm matrix on the dynamics of corrosion reactions. Also, there is the involvement of metals or organometallic complexes in electron transfer and from chemically and morphologically diverse metallic surface films to ultimate electron acceptors.
INGLÊS

Biochemical Guide To Enzymes

108,65€ + 10% EM CARTÃO

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 In this book, the authors seek to demonstrate the significant role of enzymes used in metabolomic processes. The mechanism of enzyme action is provided. This book presents the discovery, chemical structure and mechanism of action of 24 enzymes. The metabolomic functions of enzymes in treatment and diagnostics are also described.
INGLÊS

Novel Methodologies For The Synthesis Of Indole Derived Heterocyclic Scaffolds

108,65€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Indole derivatives are very important heterocyclic compounds in drug-discovery studies. They represent a very important class of molecules that play a major role in cell biology and are potential naturally occurring products. There has been an increasing interest in the use of indole derivatives as bioactive molecules against microbes, cancer cells, and various kinds of disorders in the human body. In this case, often considered to be the pre-eminent heterocycle and the molecular scaffold of greatest medicinal importance, indole continues to captivate chemists and biologists alike. Considering the reports on indole targets in the past decades, introducing new synthetic methods has been an active field of chemical research for well over a century and would be beneficial to develop new therapeutic agents. Given the enormous resurgence in indole ring synthesis over the past decade, there is a need for a comprehensive presentation of the myriad methods for constructing the indole ring: from 2010 to 2018. Due to the importance of indoles and their role in society, we are interested in collecting a book on the new methods for the synthesis of indoles derivatives. Since no book on indole structural derived scaffolds e.g. isoindole, benzoindole, fused Indoles, bis-indole and bis(indolyl)methanes, spiroindole and spirooxindole and indoloindole has been published as yet, we did not restrict ourselves to consideration of only indole synthesis but also included the results of recent studies on the synthesis of these new structures. This book attempts to illustrate the most recently used synthetic methods to prepare indole, isoindole, benzoindole, fused Indoles, bis-indole and bis(indolyl)methanes, spiroindole and spirooxindole and indoloindole and also present strategies for synthetic modification of indole via C2 functionalization of indoles, C3 functionalization of indoles and N functionalization of indoles. We have selected recent methods and examples on the basis of utility and reliability in the authentic literature or specific procedures, which are especially convenient. We invite students and professors of chemistry and pharmacy at different educational levels who want to increase their knowledge or work on the synthesis or pharmaceutical application of this class of scaffolds, to study this book in order to get acquainted with the latest methods presented.
INGLÊS

Mineral Water: From Basic Research To Clinical Applications

258,38€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Mineral Water: From Basic Research to Clinical Applications, written by a multi-disciplinary group of educators, researchers and medical doctors, gathers a timely review on the effects of mineral waters upon several aspects of human biology and pathophysiology, as it gives an overview of how mineral waters may provide a positive impact on different settings, namely health promotion and disease prevention as well as rehabilitation and therapy. A major advantage of this book is the gathering of up-to-date information on the benefits, and associated mechanisms, of mineral waters through different routes of internal and external exposure. Concepts and classifications of mineral waters are disclosed. The relevance of spa therapies in Chronic Obstructive Pulmonary Disease, otorhinolaryngology, rheumatic diseases and dermatology is addressed. The mitigation of diet-induced acid load by mineral waters consumption and its relevance for bone health is discussed. The importance of mineral waters consumption against metabolic dysfunction through gut microbiota modulation is argued. Modulation of membrane transporters by mineral water is reviewed. Mineral Water: From Basic Research to Clinical Applications aims to target health professionals (medical doctors, nurses, physiotherapists, nutritionists and dietitians), educators and students (in the aforementioned subject areas) as well as health science researchers (biochemists, biologists and pharmacists), beverage companies and policy-makers.
INGLÊS

Terpenes And Terpenoids: Sources, Applications And Biological Significance

258,38€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Terpenoids are the secondary metabolites of plant derivatives, mainly found in essential oils derived from higher plant sources. Terpenes are simple hydrocarbons, whereas terpenoids are modified terpenes containing different functional groups and oxidized methyl groups. This volume includes seven chapters examining topics related to terpenes and terpenoids. Chapter One describes mono- and sesquiterpenoids isolated from plants of the Inula L. genus and discusses biological activity of extracts and individual sesquiterpene lactones. Chapter Two covers the nature of terpenoids together with their biological activities and their isolation from endemic species from the Asteraceae family growing in Algerian Sahara and used as medicinal plants. Chapter Three introduces a catalyst system using Keggin heteropolyacid salts and hydrogen peroxide to epoxidize terpenic alcohols. Chapter Four examines the phyto-active components of terpenoids as sources of insecticide. Chapter Five describes how organic compounds containing functional groups like ketone, alcohol, and epoxide undergo rearrangement with sulfuric acid, yielding unexpected results. Chapter Six focuses on alkoxylation of terpenes over heterogenous catalysts. Lastly, Chapter Seven presents a discussion about the importance of Brazilian flora for herbal medicine.
INGLÊS

Circadian Rhythms And Their Importance

304,75€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Circadian rhythm is the mechanism for measuring time by organisms in units of around 24 hours. Almost every organism has the ability to predict daily events such as sunrise and sunset, which is essential for their optimal survival strategies. Circadian rhythms persist even in the absence of time cues and ensure that behavioral, physiological and metabolic processes align with changing environmental conditions. Most organisms, irrespective of whether they are prokaryotic or eukaryotic, have evolved certain mechanisms to sense their external environment in order to prepare a biological response. Often, these biological responses result in changes in physiology and biochemistry of organisms for the optimization of their survival. There is no unified mechanism among organisms by which sensory environment can be applied to control their lifespan. In humans, disruptions of the circadian rhythm may have an increased risk of age-related neurodegenerative diseases such as cancer, diabetes, etc. This book encompasses the most recent knowledge and modern trends in the field of circadian rhythms research. It is also expected to provide a must-read guide for beginners as well as advanced researchers in this field of study. Undergraduate, post-graduate and research scholars of several disciplines such as chemistry, botany, microbiology, biochemistry, biotechnology, bioinformatics, life sciences and bionanotechnology will benefit from this book.
INGLÊS

Biochemical View Of Antioxidants

304,75€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The Biochemical View of Antioxidants presents research on medicinal plants and organic chemistry and relates to pharmacological applications. This book discusses antioxidants, derived from fruits and vegetables, that play a vital role in maintaining health. It forms a bridge between biology and chemistry of fruits and vegetables by studying the complex nature of antioxidants. The Biochemical View of Antioxidants consists of 45 chapters. The chapters show that food constitutes a source of many biologically active antioxidants important for health and disease prevention. The antioxidant properties of fruits and vegetables have to do with the presence of tissues with natural antioxidant compounds that protect plants from free radical damage caused by oxygen in the environment or exposure to ultraviolet radiation. According to nutritionists, the most valuable source of antioxidants are fresh fruit and vegetables and natural preparations made from them, such as juices, preserves, marmalades, jams and silage.
INGLÊS

Volatile Oils: Production, Composition And Uses

304,75€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 "Volatile Oils: Production, Composition and Uses" provides a comprehensive perspective on the pertinent aspects of volatile oils, their chemistry, and their different nutraceutical properties such as antimicrobial, antioxidant and anticarcinogenic, which can be beneficial for biochemists, chemical engineers, physicians, food and agro-technologists for the development of various products. Readers will find a deep and complete perspective regarding spices and their chemical composition. The book comprises 11 chapters which cover the various aspects of volatile oils including their historical background, their extraction methods, their chemical composition and various applications in pharmaceutical and health industries. The importance of the study of volatile oil components as "green" corrosion regulators for applications in human health with additional antimicrobial properties is also documented in the book. The use of volatile oils in dental applications is mainly linked to their antimicrobial properties, useful for preventing the infections associated with dental implants and for their ability to form polymeric nanofilms on dental implants with proven antibacterial properties. Nutraceutical and life sciences companies and R&D labs will be able to utilize the information given in this book for research and development activities related to the application of spices and proactively explore and leverage the healing, nutritive and health benefits of volatile oils. The beneficial physiological properties discussed in this book will help the pharmaceutical sector also in developing preventive measures against pathologies.
INGLÊS

Systemic, Cellular And Molecular Mechanisms Of Physiological Functions And Their Disorders, Third Book (Proceedings Of I. Beritashvili Center For Expe

304,75€ + 10% EM CARTÃO

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 This edited book is the third such compilation containing chapters that represent the research priorities of the Ivane Beritashvili Center of Experimental Biomedicine, which covers the experimental study of fundamental issues in the functioning of physiological (mainly neurophysiological) mechanisms during normal and pathological conditions. The first and second books - "Systemic, Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders" - published by Nova Science Publishers Inc. in 2015 and 2018, were also devoted to the same general problems. In the present edited book, particular attention is drawn to the study of extremely important processes underlying the basic mechanisms and disorders of various phenomenon of integrative activity of the brain: general behavior, learning and memory, the sleep-wakefulness cycle, regulation of adequate blood supply, hormesis, epilepsy, depression, sleep disorders, pain and analgesia. All of the mentioned processes are studied on the molecular, cellular and systemic levels of their organization. It has to be noted that each chapter, within the collection of works, represents the results of separate, independent studies implemented by different scientific departments of the center.
INGLÊS

Introduction To Drug Carriers

212,00€ + 10% EM CARTÃO

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 The book An Introduction to Drug Carriers provides a broad overview of drug carriers. Drug carriers play medically important roles in delivering drugs to pinpointed regions in biological systems. The cell hosts most of the disorders related to diseases. Therefore, the cell is also considered the main target region for most drugs. Some of the cellular compartments, especially cell-based membranes, which are geometrically constructed with both hydrophobic and hydrophilic layers/boundaries, often appear as barriers against vital candidate drugs’ journey to the target regions. Besides, there are off-target structures that need to be avoided for drugs to get adsorbed. Otherwise, drugs may cause unbearable off-target binding originated toxicity, which would reduce the efficacy of the drugs. Appropriate choice of drug carriers may help specific drugs to get conjugated and be delivered to their optimal target structures. Biophysical and biochemical characterization of drug carriers concerning their role as vehicles to carry certain drugs may be obtained using engineering techniques. Manipulation in the cellular sites that cause disturbances in drug delivery is another biomedical option utilized to ensure smooth drug delivery. Various theoretical and experimental techniques are utilized to address all these issues related to drug carriers. The collected chapters written by experts in the field will help the subject matter be understood thoroughly.
INGLÊS

Biochemical Studies On Some Biomarkers Of Xenobiotic Exposure

de Vivek Kumar Gupta

212,00€ + 10% EM CARTÃO

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 Pesticides belonging to carbamate and organophosphate groups have the potential to induce oxidative stress. However, the role of aqueous extract of A. vera has not been properly studied to demonstrate its ameliorative potential against the toxicity induced by these pesticides in single and combination in different organs of mammalian systems. After an extensive literature survey on the subject, an endeavor has been made to define the following objectives in order to fill up the existing lacuna of information about cartap and malathion induced oxidative stress in rat blood, brain and liver and its impact on neurotransmission as well as energy metabolism. Liver and blood were also included in this study for establishing a more meaningful agreement. The present study was therefore undertaken to delineate the differential impacts of cartap and malathion on the biochemical and histological parameters in Wistar rats. In addition, the prophylactic effect of aqueous extract of A. vera leaves has also been evaluated. The objectives of the present study include: evaluation of xenobiotic-induced oxidative stress, determination of activity of acetylcholinesterase and other esterases in the brains of rats exposed to xenobiotics as potential biomarkers of neurotoxicity; evaluation of different enzymes of energy metabolism in rats exposed to xenobiotics; measurement of specific parameters concerning the function of the kidney and liver in rats exposed to xenobiotics; evaluation of AChE isozyme profile to specifically understand the target of xenobiotics in the brain of rats; analysis of patterns of major biomolecules (proteins/DNA) in rats exposed to xenobiotics for different treatment durations; and assessment of the ameliorative impact of phytochemicals, if any, on xenobiotics. This book is divided into eight sections. Section 1 contains the general introduction and background of the study. Section 2 contains an extensive literature survey on the subject so as to present updated information. Section 3 demonstrates the main objectives of the study. Section 4 describes the various experimental designs, procedures, protocols, tools and techniques. Section 5 illustrates the data obtained from this study. Section 6 enumerates the discussion of the data and associated mechanisms. Section 7 includes the summary and conclusion of the entire study. Section 8 includes citations and references used in this work. This book contains many specific diagrams, illustrations and presentations in simple tables and figures which are self-explanatory so as to make any reader well versed to this subject. In addition, specific flow charts are added to simplify the presentation.
INGLÊS

Glycome: The Hidden Code In Biology

304,75€ + 10% EM CARTÃO

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 This book addresses one of the most fundamental topics in biology today. Sugars are electroneutral. However, linking sugars to sugars, or attaching sugars to proteins or lipids changes the structural and functional identities of the glycoconjugate, and enables to form cellular networks of 4Gs [i.e., glycoproteins (N-linked or O-linked), glycosphingolipids, proteoglycans and glycosaminoglycans (GAGs)]. These glycans (i) support growth, proliferation and differentiation of cells and tissues; (ii) protect cells from foreign invasions including bacteria, viruses, parasites as well as from changes in the extracellular environment; (iii) act as biomarkers and participate in transmembrane signaling. The glycans are not ubiquitous but they are tissue/species specific. Seventeen chapters in the book are dedicated to walk the readers through the diversities of the Glycome.
INGLÊS

Resistin: Structure, Function And Role In Disease

172,25€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Over the past decade, adipose tissue has received much attention for its immunological properties. Additionally, it has become increasingly apparent that adipose-secreted factors such as leptin, tumor necrosis factor-a, IL-6, adiponectin and more recently, resistin are implicated in some inflammatory and metabolic diseases. As such, Resistin: Structure, Function and Role in Disease opens by discussing resistin's therapeutic properties. Because evidence appears to suggest that resistin is a proinflammatory cytokine, resistin may impact metabolic disease. Following this, the authors present experimental and clinical evidence indicating that resistin may have functions related to inflammation and oxidative stress. The circulating resistin level may be also useful as a marker of the effects of exercise. Resistin may also encourage vasculopathy through the promotion of macrophage scavenger receptors and CD36 atheroma macrophages expression, the formation of foam cells, as well as proliferation and migration of vascular smooth muscle cells. This causes endothelial dysfunction, resulting in limited nitric oxide and increased superoxide production. When present in the diseased vessel wall, resistin may orchestrate pro-atherosclerotic events, contributing to atherosclerosis progression towards plaque rupture. Thus, resistin may augment monocyte and macrophage infiltration, interfere in cell cross-talk and modulate the expression of various inflammatory cytokines leading to the acceleration of plaque growth. Based on the known sequential events of obesity preceding severe acute pancreatitis, the authors investigate resistin as a new potential predictive marker of fat necrosis and pancreatitis severity.
INGLÊS

Closer Look At Glycation

258,38€ + 10% EM CARTÃO

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 This well-planned, logically structured and user-friendly book provides a useful insight into the world of non-enzymatic glycation from its early stages to an advanced level, with an eye on glycating agents, their enhancers and inhibitors. All chapters are of equal interest but the chapters on dietary AGEs and effects of AGEs on bone cells provide novelty in the area of glycation. These chapters also describe characterization of the glycation and its role in different types of age-related complications and diseases. A chapter on synthetic and plant-based natural inhibitors of glycation is also presented. Written by a team of experts, this book makes the readers aware of the glycation process in various diseases and complications and creates enthusiasm in teaching key lessons to students of life and medical sciences. With the use of tables, figures and references, and a concise overview of the glycation mechanism and its inhibition on a single platform, this book is ideally suited as a resource for research and teaching purposes as well as contributes to knowledge of glycation inhibitors for controlling disease complications.
INGLÊS

Cysteine: Sources, Uses And Health Effects

108,65€ + 10% EM CARTÃO

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 Cysteine is a naturally occurring, sulfur-containing amino acid with a thiol group and is found in most proteins. Cysteine is a common constituent in health-care products like protein powders, body-building shakers, and smoothies. In medicine, it is used for the treatment of diabetes, inflammation, angina, chronic bronchitis, cardiovascular disease, flu and osteoarthritis. Also, some studies suggest that it can enhance lung health in people with chronic obstructive pulmonary disease (COPD). The first chapter of this book focuses on the uses of cysteine in both industries and medicine and health. The second chapter is about the therapeutic uses of N-acetyl cysteine (NAC) for obsessive compulsive disorder. The third chapter describes the functionalization of MCM-41 and MCM-48 by TPA, encapsulation of cysteine into functionalized carriers and their characterization using various physicochemical techniques. The last chapter includes the most recent developments in designing the fluorescent and colorimetric sensors (optical sensors) for selective and sensitive detection of cysteine.
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