Resultados de Pesquisa

INGLÊS

Scf And Apc E3 Ubiquitin Ligases In Tumorigenesis

de Hiroyuki Inuzuka e Wenyi Wei

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
INGLÊS

Quick Guide To Cancer Epidemiology

de Carlo La Vecchia, Paolo Boffetta e Stefania Boccia

72,86€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 A Quick Guide to Cancer Epidemiology is an ideal addition to Springer Briefs in Cancer Research. The Brief provides core concepts in cancer epidemiology and also gives a snapshot of the epidemiology of seventeen human cancers. The Brief aims to provide-with quantitative focus-estimates of the global burden of neoplasms, of recent and likely future trends, distribution, causes and strategies for prevention for major groups of cancers. Finally, the Brief will give an overview of severals factors that cause cancer including dietary factors, tobacco smoking, obesity and alcohol consumption.
INGLÊS

Mirnas And Target Genes In Breast Cancer Metastasis

de Seema Sethi

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy. The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically modified anti-miRNA oligonucleotides), which could prevent the development of metastasis; whereas once metastasis develops then it could be treated with miRNA mimics for inducing its expression for the treatment. Therefore, development of miRNA-based prophylactic therapies could serve as precision and personalized medicine against future development of metastasis of breast and other cancers.
INGLÊS

Hepatocellular Carcinoma - Cellular And Molecular Mechanisms And Novel Therapeutic Strategies

de Clifford J. Steer e Rajagopal N. Aravalli

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book provides up-to-date information on the development and progression of hepatocellular carcinoma (HCC) with a review of the cellular and molecular mechanisms involved in the disease process.
INGLÊS

Systems Biology Of Tumor Physiology - Rethinking The Past, Defining The Future

de David H. Nguyen

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level.
INGLÊS

New Insights On Vitamin C And Cancer

de Jorge R. Miranda-Massari e Michael J. Gonzalez

70,21€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Research on vitamin C and its effects on cancer is growing in popularity around the world as positive research continues to accumulate building a stronger case for its effectiveness. This concise SpringerBrief on Vitamin C and Cancer presents the latest findings on how vitamin C induces apoptosis. A high concentration of vitamin C allows for ascorbate to generate hydrogen peroxide in tissue that can selectively kill cancer cells. Research has confirmed that high-dose vitamin C is cytotoxic to a wide variety of cancer cell lines, and that it also boosts the anti-cancer activity of several common chemotherapy drugs. Vitamin C also does more than just kill cancer cells. It boosts immunity by stimulating collagen formation to help the body wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade other organs throughout the body. This concise and up-to-date Brief is geared towards cancer researchers and scientists, as well as physicians interested in the basic science and the translational potential of vitamin C in cancer therapeutics.
INGLÊS

Obesity And Breast Cancer - The Role Of Dysregulated Estrogen Metabolism

de Evan R. Simpson e Kristy A. Brown

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book discusses the connection between obesity and breast cancer in older women. It explores the application of novel therapies to inhibit aromatase in the breast.
INGLÊS

Ebna1 And Epstein-Barr Virus Associated Tumours

de Lori Frappier

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This SpringerBrief offers a comprehensive account of the functions and effects of the Epstein-Barr virus EBNA1 protein relating to EBV-associated cancers, including how EBNA1 manipulates specific cellular proteins and relationships to lymphomas and carcinomas.
INGLÊS

Mhc Class I Antigens In Malignant Cells - Immune Escape And Response To Immunotherapy

de Angel Miguel Garcia-Lora, Natalia Aptsiauri e Teresa Cabrera

59,61€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book discusses abnormal expression of MHC class I molecules in malignant cells, explaining how MHC class 1 is expressed, and its role in tumor progression. Includes new discoveries by the authors on the role of MHC class 1 in resistance to immunotherapy.
INGLÊS

A Valentine Weekend: S.N.C.W.S. - S.N.C.W.S.

de Gerald E. Moutra

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INGLÊS

A Valentine Weekend: S.N.C.W.S. - S.N.C.W.S.

de Gerald E. Moutra

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INGLÊS

Guide To Common Cross Cover Calls

de Dr. Sunita S D M.D.

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Macey Harold: Attorney At Law - Attorney At Law

de Gwynn Braswell

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INGLÊS

Faith Is Part Of Human Existence: (This Is God`S Will And It Doesn`T Change) - (This Is God'S Will And It Doesn'T Change)

de Rafig Y. Aliyev

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INGLÊS

Thy Divine Witness: Physican, Heal Thyself! Luke 4:23 - Physican, Heal Thyself! Luke 4:23

de Nefertari O'Neal

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INGLÊS

Thy Divine Witness - Physican, Heal Thyself! Luke 4:23

de Nefertari O'Neal

17,75€

portes grátis

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INGLÊS

'Tales From The Tale': A 'Whale' Of A Guide To Seafood Cookery - A 'Whale' Of A Guide To Seafood Cookery

de Philip Andriano

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INGLÊS

"The Crow'S Cry 2"

de Anastasia Shmaryan

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INGLÊS

It'S All Straw

de Richard R. Sooley

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INGLÊS

It'S All Straw

de Richard R. Sooley

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INGLÊS

A Matter For Time

de George Acker

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The Inner Being

de Duria Jacobs

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Sex As . . .: A Journal For Your Life - A Journal For Your Life

de Jeff Devore

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Sex As . . .: A Journal For Your Life - A Journal For Your Life

de Jeff Devore

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