Resultados de Pesquisa

INGLÊS

Neonatal Immunity

de Constantin Bona

171,59€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants.
INGLÊS

Lupus - Molecular And Cellular Pathogenesis

330,59€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.
INGLÊS

Molecular Biology Of B-Cell And T-Cell Development

237,84€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
INGLÊS

Cytokine Knockouts

95,40€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func- tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al- though the latter finding is of course a wonderful incentive for fur- ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem- bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.
INGLÊS

Blys Ligands And Receptors

237,84€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Centers on the BLyS(BAFF) family of ligands and receptors. This book covers basic and translational/clinical aspects of this molecular family's biology. It focuses on the BLyS family's role in the differentiation, selection, and regulation of primary and antigen-experienced B cells.
INGLÊS

Chemokines In Disease - Biology And Clinical Research

237,84€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Caroline Hebert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology.
INGLÊS

Cytokine Knockouts

237,84€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology.
INGLÊS

Therapeutic Interventions In The Complement System

118,59€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 A team of expert investigators and clinical researchers comprehensively review complement''s basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, spelling out the activation pathways and complement receptors. Informative animal models are discussed in detail, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. The emphasis throughout is on the pros and cons of the therapeutic use of recombinant complement inhibitors in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for today''s researcher and biotechnologist effective strategies of drug discovery and development that are producing valuable new complement inhibitors for the treatment of a wide variety of clinically important diseases.
INGLÊS

Immunosuppression And Human Malignancy

de Benjamin Y. Klein, David Naor, Jonathan S. Duke-Cohan e Nora Tarcic

118,59€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Professor Naor and his colleagues have written a book that explores another possible reason: cancer cells are recognized by the immune system-but is it possible that the consequence of recognition is inhibition of the immune system-by suppressor T cells or macrophages?
INGLÊS

Autoimmune Reactions

171,59€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms.
INGLÊS

Blys Ligands And Receptors

202,77€ + 10% EM CARTÃO

portes grátis

 Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activation, and homeostasis.
INGLÊS

Autoimmune Reactions

175,73€ + 10% EM CARTÃO

portes grátis

 The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms.
INGLÊS

Neonatal Immunity

de Constantin Bona

175,73€ + 10% EM CARTÃO

portes grátis

 A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants.
INGLÊS

Molecular Biology Of B-Cell And T-Cell Development

237,26€ + 10% EM CARTÃO

portes grátis

 Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
INGLÊS

Cytokine Knockouts

243,33€ + 10% EM CARTÃO

portes grátis

 Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology.
INGLÊS

Autoimmune Reactions

175,73€ + 10% EM CARTÃO

portes grátis

 The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms.
INGLÊS

Clinical Cellular Immunology - Molecular And Therapeutic Reviews

de Albert A. Luderer e Howard H. Weetall

118,59€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA
INGLÊS

Lance & Leo

de Aalto Colton Aalto

ESGOTADO OU NÃO DISPONÍVEL

 An erotic novel about a young man abducted from the present, taken to the future, all to save the past: When Cody Montrose is about to lose his virginity, the hookup is interrupted by men from the year 2060, who want him to be a test subject sent back to 1980s California, to impersonate Lance, a blond porn star of the era.
INGLÊS

The Bear Who Wasn'T There And The Fabulous Forest

de Oren Lavie; Ilustração: Wolf Erlbruch

23,11€

portes grátis

ESGOTADO OU NÃO DISPONÍVEL
INGLÊS

The Worst Breakfast

de China Miéville; Ilustração: Zak Smith

ESGOTADO OU NÃO DISPONÍVEL
INGLÊS

Friday Memories - The Life And Times Of June Friday Macinnis

de June Friday Macinnis

ESGOTADO OU NÃO DISPONÍVEL
INGLÊS

La Dispensa De Ilegales Es: Anarquia O Justicia - Anarquia O Justicia

de Hugo Aguilera

ESGOTADO OU NÃO DISPONÍVEL
INGLÊS

En Proceso De Metamorfosis

de Miguel Matias Duro

ESGOTADO OU NÃO DISPONÍVEL
INGLÊS

En Proceso De Metamorfosis

de Miguel Matias Duro

ESGOTADO OU NÃO DISPONÍVEL
A carregar resultados...

Ver mais resultados