Resultados de Pesquisa

INGLÊS

Cortico-Subcortical Dynamics In Parkinson'S Disease

~~131,84€~~ 105,47€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network (3â€"5).
INGLÊS

Opiate Receptors And Antagonists - From Bench To Clinic

~~171,59€~~ 137,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders, traumatic injury, pruritis, and movement disorders. These potential treatments involve both novel chemical entities and classic opioid antagonists with improved drug delivery systems. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent the efforts from some of the leading international scientists and clinicians making use of the l- est information emerging from the study of the opioid receptor system. Given the number of researchers currently active in this and related fields of study, it would be inappropriate to suggest that the entire range of activities is fully reflected in this single volume. Instead, a variety of experimental and clinical approaches involving the fields of neuroscience, molecular biology, biochemistry, anatomy, pharmacology, psychology, and psychiatry have been chosen to illustrate rapidly developing experimental and therapeutic areas.
INGLÊS

Mitochondrial Inhibitors And Neurodegenerative Disorders

~~171,59€~~ 137,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.
INGLÊS

Central Nervous System Diseases - Innovative Animal Models From Lab To Clinic

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

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 A critical review of the animal models used in developing powerful new therapies for central nervous system diseases. Techniques that rely heavily on behavioural analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated.
INGLÊS

Cerebral Ischemia - Molecular And Cellular Pathophysiology

~~59,61€~~ 47,69€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption.
INGLÊS

Gene Therapy For Neurological Disorders And Brain Tumors

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology.
INGLÊS

Highly Selective Neurotoxins - Basic And Clinical Applications

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants.
INGLÊS

Cell Transplantation For Neurological Disorders - Toward Reconstruction Of The Human Central Nervous System

~~171,59€~~ 137,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This text covers such topics as: somatotopic organization of the striatum and its relevance to neural transplantation; evaluation of patients with Parkinson's disease; the Lund Transplant Program (Parkinson's disease and MPTP patients); and the Paris Program.
INGLÊS

Antidepressants - New Pharmacological Strategies

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This text provides valuable insights into the recent pharmacological advances in the development of newer and more effective therapies.
INGLÊS

Molecular Mechanisms Of Dementia

~~131,84€~~ 105,47€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer''s disease (AD), an assortment of other less common disorders, such as prion and Pick''s disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.
INGLÊS

Neurotransmitter Transporters - Structure, Function, And Regulation

~~95,40€~~ 76,32€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 A comprehensive survey of recent advances made in characterizing neurotransmitter transporters-including their imaging in the living brain-and in elucidating the processes underlying biological transport. The expert contributors present up-to-date findings on the molecular cloning of transporters and on neurotransmitter families both in plasma membranes and in storage vesicles. They also provide essential information on the structure-activity relationships for a multitude of recently synthesized dopamine uptake blockers, on transporter changes in the context of human drug abuse, and on the role of transporters in the action of uptake blockers in vivo. The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs of abuse, and neurotoxins. <BR><BR>
INGLÊS

Biology Of Neuropeptide Y And Related Peptides

de Claes Wahlestedt e William F. Colmers

~~171,59€~~ 137,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Leading experts critically summarize the state of knowledge concerning the molecular, anatomical, physiological, and behavioral aspects of NPY and its congeners. Each article provides a comprehensive and in-depth survey, an overview of the role of NPY in the discipline covered, a discussion of the likely future direction that the field will take, and an up-to-date bibliography.<BR>Chapters include a treatment of the evolution of the PP family of genes, the structure of the NPY gene, and the distribution of NPY on the cardiovascular system, actions of NPY on the electrophysiological properties of nerve cells, and the effects of NPY on feeding and behavior. The chapters are written in an accessible style and serve both as an introduction to the field and as an extensive and detailed treatment of the current state of knowledge.
INGLÊS

Voltammetry In The Neurosciences - Principles, Methods, And Applications

de Jr. Justice

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Schmitt to establish the Neuroscience Re- search Program and the later development of the Society for Neuroscience, there has emerged a large and powerful multi- disciplinary research force devoted to understanding even the ru- dimentary aspects of brain functioning.
INGLÊS

Experimental Psychopharmacology

de Andrew J. Greenshaw e Colin T. Dourish

~~171,59€~~ 137,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Psychopharmacology may be defined as the study of the effects of drugs on behavior. Numerous excelIent texts and review articles are available that serve to outline recent progress in psychopharmacology (particularly the Handbook of Psychopharmacology series, edited by L.
INGLÊS

Neurobiology Of The Trace Elements - Volume 2: Neurotoxicology And Neuropharmacology

de Ivor E. Dreosti e Richard M. Smith

~~118,59€~~ 94,87€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This text is a treatise drawing together and critically examining the current explosion of experimental and clinical research on the metabolism, nutrition, pharmacology, toxicology, pathology, neuropsychology, and developmental neurobiology of trace elements.
INGLÊS

Neural Stem Cells For Brain And Spinal Cord Repair

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain.
INGLÊS

Neuroinflammation - Mechanisms And Management

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.
INGLÊS

Neurotransmitter Transporters - Structure, Function, And Regulation

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This work provides a comprehensive survey of contemporary advances made in characterizing neurotransmitter transporters - including their imaging in the living brain - and in elucidating the processes underlying biological transport.
INGLÊS

Neuronal Environment - Brain Homeostasis In Health And Disease

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Offers a perspective on neuronal function by examining its components, including their pertubation during disease states, and relates various elements to neuronal demands. This book addresses the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, and more.
INGLÊS

Stem Cells And Cns Development

~~171,59€~~ 137,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Reviews the findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. This book defines the classes of stem cells in the nervous system, compares their similarities and differences and discusses the gains made in identifying human homologs of neural stem cells.
INGLÊS

Pathogenesis Of Neurodegenerative Disorders

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases.
INGLÊS

Neuroglia In The Aging Brain

~~237,84€~~ 190,27€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Reviews the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. This book shows how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.
INGLÊS

Mammalian Brain Development

~~131,84€~~ 105,47€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The even more colo- ful â€œbook of lifeâ€ metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.
INGLÊS

New Strategies In Stroke Intervention - Ionic Transporters, Pumps, And New Channels

~~131,84€~~ 105,47€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book on stroke intervention is a groundbreaking review of ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure.
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