Resultados de Pesquisa

INGLÊS

Machine Learning And Deep Learning In Drug Design

~~268,90€~~ 242,01€ 10% IMEDIATO

 Explores how machine learning and deep learning revolutionize drug design, covering applications from target discovery to toxicity prediction and virtual screening across the drug pipeline.
INGLÊS

Ion Channel Drug Discovery

~~176,21€~~ 140,97€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.
INGLÊS

Orphan Drugs And Rare Diseases

~~231,88€~~ 185,50€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Orphan drugs are designated drug substances that are intended to treat rare or 'orphan' diseases. More than 7000 rare diseases are known that collectively affect some 6-7% of the developed world's population; however, individually, any single, rare disease may only affect a handful of people making them commercially unattractive for the biopharmaceutical industry to target.Ground breaking legislation, starting with the Orphan Drug Act that was passed in the US in 1983 to provide financial incentives for companies to develop orphan drugs, has sparked ever increasing interest from biopharmaceutical companies to tackle rare diseases. These developments have made rare diseases, and the orphan drugs that treat them, sufficiently attractive to pharmaceutical development and many pharmaceutical companies now have research units dedicated to this area of research. It is therefore timely to review the area of orphan drugs and some of the basic science, drug discovery and regulatory factors that underpin this important, and growing, area of biomedical research.Written by a combination of academic and industry experts working in the field, this text brings together expert authors in the regulatory, drug development, genetics, biochemistry, patient advocacy group, medicinal chemistry and commercial domains to create a unique and timely reference for all biomedical researchers interested in finding out more about orphan drugs and the rare diseases they treat.Providing an up-to-date monograph, this book covers the basic science, drug discovery and regulatory elements behind orphan drugs and will appeal to medicinal and pharmaceutical chemists, biochemists and anyone working within the fields of rare disease research and drug development or pharmaceuticals in industry or academia.
INGLÊS

Macrocycles In Drug Discovery

~~231,88€~~ 185,50€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules.A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.
INGLÊS

Carbohydrates In Drug Design And Discovery

~~223,93€~~ 179,14€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery.Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery.Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.
INGLÊS

Green Chemistry Strategies For Drug Discovery

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included.This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.
INGLÊS

New Horizons In Predictive Drug Metabolism And Pharmacokinetics

~~231,88€~~ 185,50€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound's metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities.Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.
INGLÊS

Nanomedicines - Design, Delivery And Detection

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Nanomedicines and nanopharmacology is a rapidly developing and evolving field with new techniques and applications under constant development. This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine. Providing an understanding of the relationship of nanocarrier, drug and targetting moieties and physico-chemical properties, this title will provide an accurate and current representation of the field by addressing the promises, prospects and pitfalls of nanomedicine. Covering a wide range of areas in detail, this book will provide an excellent companion for medicinal chemists, pharmacologists and biochemists working in industry or academia.
INGLÊS

Synthetic Methods In Drug Discovery - Volume 2

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
INGLÊS

Drug Transporters - Volume 2: Recent Advances And Emerging Technologies

~~210,68€~~ 168,54€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field.The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.
INGLÊS

Synthetic Methods In Drug Discovery - Volume 1

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
INGLÊS

Epigenetics For Drug Discovery

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia.The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs.Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.
INGLÊS

Allosterism In Drug Discovery

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future.This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.
INGLÊS

Drug Transporters - Volume 1: Role And Importance In Adme And Drug Development

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.
INGLÊS

Privileged Scaffolds In Medicinal Chemistry - Design, Synthesis, Evaluation

~~237,18€~~ 189,74€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
INGLÊS

High Content Imaging In Drug Discovery

~~237,18€~~ 213,46€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 The breadth of available technology and the biology to which high content imaging is applied is vast. This comprehensive resource covers state-of-the-art technologies, essential supporting infrastructure and data analysis approaches to support pre-clinical drug discovery.
INGLÊS

Dna-Encoded Library Technology For Drug Discovery

~~197,43€~~ 177,69€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.
INGLÊS

High Content Imaging In Drug Discovery

~~241,99€~~ 217,79€ 10% IMEDIATO

portes grátis

 The breadth of available technology and the biology to which high content imaging is applied is vast. This comprehensive resource covers state-of-the-art technologies, essential supporting infrastructure and data analysis approaches to support pre-clinical drug discovery.
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Methods In Microarray Normalization

eBook 25%

INGLÊS

Methods In Microarray Normalization

~~74,19€~~ 59,35€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Compiles useful normalization methods developed for interpreting microarray data. This book examines the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review modern software, including discussions on key algorithms, comparative data, and download locations.
INGLÊS

Handbook Of Assay Development In Drug Discovery

~~311,38€~~ 249,10€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Describes the tools available for performing various assay techniques. This book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system and troubleshooting tools. It describes biochemical assay classes and non-class specific assay development for cell-based assays.
INGLÊS

Functional Protein Microarrays In Drug Discovery

~~311,38€~~ 249,10€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Explores various aspects of functional protein microarrays, including basic principles, methods, and applications. This book discusses the generation of functional protein content and describes fabrication methods. It presents a range of applications, from biomolecular interaction discovery and characterization to immune response profiling.
INGLÊS

Biochips As Pathways To Drug Discovery

~~87,44€~~ 69,95€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 Explores the tools and skills required at each step of the discovery process when using biochips to determine biological outcomes. This work provides a review of the clinical and pharmacogenomic relevance of biochips, ChIP-chip assays, and high-throughput approaches.
INGLÊS

Industrialization Of Drug Discovery - From Target Selection Through Lead Optimization

~~67,56€~~ 54,05€ 20% IMEDIATO + 5% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The pharmaceutical industry suffers from an innovation deficit, with clinical attrition and safety-related market-withdrawal rates at the same level as twenty years ago. This book scrutinizes this problem in detail, contrasting the promise of technology and industrialization with the apparent inability of industry to fully realize the tools that ar
INGLÊS

High Content Imaging In Drug Discovery

~~237,18€~~ 213,46€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 The breadth of available technology and the biology to which high content imaging is applied is vast. This comprehensive resource covers state-of-the-art technologies, essential supporting infrastructure and data analysis approaches to support pre-clinical drug discovery.
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