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INGLÊS

Marek'S Disease

101,38€ + 10% EM CARTÃO

portes grátis

 Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. This work gives an overview on many aspects of MDV research and summarizes advances in the field. The topics include the history, biology and molecular biology of MDV.
INGLÊS

Immunoreceptor Tyrosine-Based Inhibition Motifs

97,34€ + 10% EM CARTÃO

portes grátis

 This volume contains 15 reviews written by authors who made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties.
INGLÊS

Arenaviruses - The Molecular Pathogenesis Of Arenavirus Infections

97,34€ + 10% EM CARTÃO

portes grátis

 The second volume of "Arenaviruses" deals with the biology and pathogenesis of arenaviruses primarily through the study of LCMV. The observation of MHC restriction and CD8 cytotoxic T lymphocyte killing - initially from studies with LCMV in mice - has been expanded to human pathogens.
INGLÊS

Epstein-Barr Virus And Human Cancer

97,34€ + 10% EM CARTÃO

portes grátis

 Epstein-Barr virus (EBV), a human herpes virus, originally received attention because of its associations with Burkitt's lymphoma and nasopharyngeal carcinoma. EBV is ubiquitous in the human population and most people carry the virus in memory B-cells in a latent stage. In this book, US and Japanese researchers review progress in EBV research.
INGLÊS

Human Challenge Studies For Vaccine Development

~~243,33€~~ 219,00€ 10% IMEDIATO

portes grátis

 This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest.
INGLÊS

Human Challenge Studies For Vaccine Development

~~237,84€~~ 214,06€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest.
INGLÊS

Varicella-Zoster Virus - Genetics, Pathogenesis And Immunity

189,25€ + 10% EM CARTÃO

portes grátis

 This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus.
INGLÊS

Helicobacter Pylori And Gastric Cancer

~~189,25€~~ 170,33€ 10% IMEDIATO

portes grátis

 This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer.
INGLÊS

Pi3k And Akt Isoforms In Immunity - Mechanisms And Therapeutic Opportunities

175,73€ + 10% EM CARTÃO

portes grátis

 This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death.
INGLÊS

Helicobacter Pylori And Gastric Cancer

~~184,84€~~ 166,36€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer.
INGLÊS

Alternate Programmed Cell Death Signaling In Antiviral Host Defense

~~158,34€~~ 142,51€ 10% IMEDIATO

DISPONIBILIDADE IMEDIATA

 <p>This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system.</p><p>Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus.</p><p>Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV)where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. </p><p>This volume is a must-read for researchers and advanced students in immunology and virology.</p>
INGLÊS

Sex And Gender Differences In Infection And Treatments For Infectious Diseases

211,99€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 <p>This fully revised and significantly expanded second edition examines sex and gender differences in the immune system''s response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents.</p><p>This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).<br></p>
INGLÊS

Lassa Fever: Epidemiology, Immunology, Diagnostics, And Therapeutics

198,09€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This volume provides a comprehensive and up-to-date overview of the various aspects of Lassa virus (LASV), the causative agent of Lassa fever, a frequently fatal zoonotic disease endemic to West Africa. Compiled by world-leading experts in the field, this book provides an introduction to the 50-year history of Lassa fever research, the genetic diversity of LASV, and its geographic distribution. Subsequent chapters focus on the ecology and epidemiology of LASV, discussing in-depth the interactions of the virus with its hosts - multimammate mice and other rodents - and the interactions between these animal reservoirs and humans. The book also details the many advances in understanding the structural biology and replication of LASV, including new insights into the structure and function of its proteins. These advances in the basic understanding of LASV biology have enabled the development of LASV countermeasures, including sensitive and specific diagnostic assays. Promising drugcandidates, including monoclonal antibodies, and vaccines are also discussed. A final and essential chapter addresses current and future clinical practice for clinical management of Lassa fever. <div><br><div>This volume is intended for researchers and clinicians in the fields of virology, epidemiology, and microbiology.</div></div>
INGLÊS

Urinary Fistula

175,73€ + 10% EM CARTÃO

portes grátis

 Although the condition of fistula is universal, this new book addresses not only obstetric fistulas that have been the most studied, but also those that affect men and those related to specific situations such as kidney transplantation.
INGLÊS

Fibers - History, Production, Properties, Market

de Dieter Veit

189,25€ + 10% EM CARTÃO

portes grátis

 This textbook covers the production of all relevant natural and man-made fibers, their inner structure, properties, applications, markets and historic development. The properties of important fibers are compared in a large number of tables and graphics to simplify selecting an appropriate fiber for a given application.
INGLÊS

Varicella-Zoster Virus - Genetics, Pathogenesis And Immunity

189,25€ + 10% EM CARTÃO

portes grátis

 This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus.
INGLÊS

Pi3k And Akt Isoforms In Immunity - Mechanisms And Therapeutic Opportunities

175,73€ + 10% EM CARTÃO

portes grátis

 This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death.
INGLÊS

Chikungunya Virus

202,77€ + 10% EM CARTÃO

portes grátis

 This book provides readers with a collection of latest reviews written by Chikungunya virus (CHIKV) research leaders who cover topics related to CHIKV replication, advances in CHIKV research reagents and model system development, as well as the pathogenesis of chronic CHIKV disease.
INGLÊS

Bone Marrow Niche - Microenvironments Critical For Immune Cell Development

175,73€ + 10% EM CARTÃO

portes grátis

 Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow.
INGLÊS

Pharmacokinetics And Pharmacodynamics Of Nanoparticulate Drug Delivery Systems

337,96€ + 10% EM CARTÃO

portes grátis

 A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems.
INGLÊS

Fungal Extracellular Vesicles - Biological Roles

202,77€ + 10% EM CARTÃO

portes grátis

 This book provides an in-depth overview on the manifold functions of fungal extracellular vesicles (EV) which span from cell-to-cell communication, pathogenicity and stimulation of hostâ€™s immunity to export of hundreds of biomolecules.
INGLÊS

Mrna Vaccines

184,84€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic,low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health.<p> </p><p>As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.</p><p></p>
INGLÊS

Viral Fitness And Evolution - Population Dynamics And Adaptive Mechanisms

211,34€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 <p>This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness.</p><p>Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. <br>By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored.<br> Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic.</p><p>The book is aimed at students and scientists interested in basic and applied aspectsof plant and animal virus population dynamics and evolution.</p><div><br></div>
INGLÊS

Varicella-Zoster Virus - Genetics, Pathogenesis And Immunity

184,84€ + 10% EM CARTÃO

DISPONIBILIDADE IMEDIATA

 This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus.
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