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Chemoenzymatic Synthesis Of Natural Products And Complex Small Molecules

~~278,50€~~ 250,65€ 10% OFF

 The total synthesis of structurally complex natural products has challenged and inspired generations of chemists. However, despite their history as privileged bioactivity-rich scaffolds, the use of natural products in drug discovery has waned. Recent developments in biocatalysis have resulted in the application of enzymes for the construction of complex molecules. This dynamically developing field is increasingly becoming a competitive alternative for classical total synthesis. Giving readers an in-depth overview of the current state of the field, this book will be of wide interest to natural products and drug researchers with a chemical or biochemical background and biocatalysis experts in academia and industry. Chapters include emerging enzymes from biosynthetic pathways, enzymes for building block synthesis and late-stage derivatisation as well as the formation of specific structural elements, such as chiral amines and heterocycles. Other important aspects for the efficient chemoenzymatic synthesis of bioactive molecules include the development of multi-enzyme cascades, engineered enzymes and strategic considerations for the use of biocatalysts in the synthesis of natural products and synthetic drugs.
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Imaging Tools For Chemical Biology

~~269,02€~~ 242,12€ 10% OFF

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 An in-depth overview of the current state-of-the-art application of multimodal and combined techniques used for imaging applications in chemical biology.
Imaging Tools For Chemical Biology

~~263,68€~~ 237,31€ 10% OFF

 This book provides a comprehensive overview of multimodal and combined techniques used for imaging applications in Chemical Biology, including afterglow luminescence imaging, chemiluminescence imaging, delayed fluorescence imaging, AIE fluorescence imaging, and many more techniques. As well as providing in-depth detail on the application of these techniques, the advantages and disadvantages of each are also discussed. Additionally, Imaging Tools for Chemical Biology also covers the use of chemical probes for tagging biomolecules and therapeutic applications. The current state of the art in biological imaging and future directions for the field are also discussed and evaluated. This book is a valuable resource and ideal for researchers new to the area, as well as experienced chemists interested in developing probes and biologists interested in utilising probes in their research.
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Quorum Quenching - A Chemical Biological Approach For Microbial Biofilm Mitigation And Drug Development

237,18€ + 10% CARD

 Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new therapeutics is inhibition of quorum sensing: how microorganisms communicate and form biofilms in a density-dependent manner. Inhibiting this system via ‘quorum quenching’ (QQ) is a promising route to new pharmaceuticals and for controlling biofilm formation and growth. Quorum sensing also provides interesting possibilities in synthetic biology for producing novel products, biosensors, bioactive molecules, and so on. This book covers the biology of quorum sensing and quenching, and potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications. The book also covers the potential for new drug development from QQ, covering a range of related topics including protein engineering, imaging and computational studies, and integrated systems. This book is an ideal companion to researchers in chemical biology and medicinal chemistry, particularly those interested in biofilm formation, quorum sensing, novel antimicrobial development, synthetic biology and enzymology.
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Quorum Quenching - A Chemical Biological Approach For Microbial Biofilm Mitigation And Drug Development

241,99€ + 10% CARD

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 This book covers the biology of quorum sensing and quenching, potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications.
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Chemical Biology Of Nitrogen

by Christopher T (Stanford University, Usa) Walsh

241,99€ + 10% CARD

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 The Chemical Biology of Nitrogen book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics.
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Dna Damage, Dna Repair And Disease - Volume 2

241,99€ + 10% CARD

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 The overall aim of these books is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
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Inhibitors Of Proteinâ€“Protein Interactions - Small Molecules, Peptides And Macrocycles

214,95€ + 10% CARD

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 Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
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Dna Damage, Dna Repair And Disease - Volume 1

228,47€ + 10% CARD

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 The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
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Chemical Biology Of Phosphorus

by Christopher T (Stanford University, Usa) Walsh

241,99€ + 10% CARD

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 Covering the breadth of phosphorus chemistry in biology, this book is ideal for biochemistry students, postgraduates and researchers interested in the chemical logic of phosphate metabolites, energy generation, biopolymer accumulation and phosphoproteomics.
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Dna-Targeting Molecules As Therapeutic Agents

214,95€ + 10% CARD

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 This book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment.
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Oxidative Folding Of Proteins - Basic Principles, Cellular Regulation And Engineering

241,99€ + 10% CARD

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 With contributions from experts in the field, this book provides a comprehensive overview of the oxidative folding of cysteine-rich proteins.
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Mechanisms Of Primary Energy Transduction In Biology

228,47€ + 10% CARD

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 An essential resource for biochemists, biophysicists and chemical biologists, providing a complete understanding of the molecular machines of bioenergetics.
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Protein Crystallography - Challenges And Practical Solutions

214,95€ + 10% CARD

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 Forthcoming books in the series will provide authoritative coverage of research areas where chemistry is used to solve biological questions for postgraduate students and above.
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Cyclic Peptides - From Bioorganic Synthesis To Applications

228,47€ + 10% CARD

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 This book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to utility in biology and drug discovery.
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Mechanisms Of Primary Energy Transduction In Biology

223,93€ + 10% CARD

 An essential resource for biochemists, biophysicists and chemical biologists, providing a complete understanding of the molecular machines of bioenergetics.
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Computational Tools For Chemical Biology

237,18€ + 10% CARD

 This book offers a fresh perspective on how computational tools can aid the chemical biology research community and drive new research.
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Computational Tools For Chemical Biology

241,99€ + 10% CARD

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 This book offers a fresh perspective on how computational tools can aid the chemical biology research community and drive new research.
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High Throughput Screening Methods - Evolution And Refinement

241,99€ + 10% CARD

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 This book serves as a practical reference for the current state of the art in high throughput screening, which remains a key part of early stage drug and tool compound discovery.
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High Throughput Screening Methods - Evolution And Refinement

197,43€ + 10% CARD

 High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.
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Chronobiology And Chronomedicine - From Molecular And Cellular Mechanisms To Whole Body Interdigitating Networks

242,12€

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 Chronobiology and Chronomedicine is an ideal introduction for postgraduates in various fields, reviewing developments and outlining methods to show the depth and breadth of chronobiology, as well as an invaluable companion to researchers with an interest in developing novel therapeutic approaches.
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Chronobiology And Chronomedicine - From Molecular And Cellular Mechanisms To Whole Body Interdigitating Networks

~~263,68€~~ 237,31€ 10% OFF

 Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for the difference between life and death in response to identical stimulus. The partly endogenous nature of circadian rhythms has been well documented and methods for their characterisation have been developed enabling the cellular and molecular mechanisms to be understood. Chronobiology and Chronomedicine aims to provide a review of these mechanisms underlying circadian rhythms and illustrate the role of the brain’s suprachiasmatic nuclei in the ‘pace-making’ process and the effects caused by ‘clock genes’ present in almost all cells. Beyond the mechanisms involved, the book discusses the relationship between body systems, disease, and proper circadian function; in particular, how disruption of the circadian rhythm is associated with ill health and disease status from observations made at the organismic level. The book is organised to be an ideal introduction for the postgraduate in various fields, reviewing developments and outlining methods to show the depth and breadth of chronobiology and chronomedicine, as well as an invaluable companion to researchers and healthcare professionals working in the field with an interest in developing novel therapeutic approaches.
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Chemical Biology Of Carbon

by Christopher T (Stanford University, Usa) Walsh

241,99€

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 The Chemical Biology of Carbon examines chemical biology open to carbon-containing natural metabolites that allow both retrospective and predictive behaviours of both biosynthetic and degradative metabolism in primary and secondary pathways ideal for medicinal chemists, chemical biologists and postgraduate students.
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Chemical Biology Of Carbon

by Christopher T Walsh

237,18€ + 10% CARD

 Building upon the previous volumes, The Chemical Biology of Sulfur, The Chemical Biology of Phosphorus, and The Chemical Biology of Nitrogen, this book examines the organic chemistry of life, The Chemical Biology of Carbon. It examines chemical biology open to carbon-containing natural metabolites that allow both retrospective and predictive behaviours of both biosynthetic and degradative metabolism in primary and secondary pathways. This book also notes the centrality of a core set of heterocycles in metabolites and coenzyme forms of vitamins and how that chemistry enables life. The organic chemical fundamental considerations are always tied to specific metabolites and metabolic transformations. This context makes this volume not a classical organic or even bioorganic approach to organic chemistry in vivo but instead a unique analysis of how the rules and reactivities of organic chemistry underlie the organic chemistry of life. The Chemical Biology of Carbon is an ideal reference and guide for medicinal chemists, chemical biologists, organic chemists as well as postgraduate, graduate and advanced undergraduate students in these areas and related disciplines.
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