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Target Discovery And Validation - Methods And Strategies For Drug Discovery

185,50€ + 10% CARD

 The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
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Innovative Dosage Forms - Design And Development At Early Stage

185,50€ + 10% CARD

 Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.
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Neglected Tropical Diseases - Drug Discovery And Development

180,20€ + 10% CARD

 A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.
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Epigenetic Drug Discovery

201,40€ + 10% CARD

 This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins.
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Biomolecular Simulations In Structure-Based Drug Discovery

165,63€ + 10% CARD

 A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design. The first part of this practical guide for industry professionals describes common tools used in the biomolecular simulation of drugs and their targets.
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Early Drug Development - Bringing A Preclinical Candidate To The Clinic

351,13€ + 10% CARD

 This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.
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Epigenetic Drug Discovery

208,12€ + 10% CARD

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 This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins.
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Protecting Groups: Strategies And Applications In Carbohydrate Chemistry

178,38€ + 10% CARD

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 Written by a team of world-class leaders from academia and industry, this is a unique overview of the most important protecting group strategies in modern carbohydrate chemistry. Clearly divided into two parts, the first focuses on those groups best used to protect a specific position on a carbohydrate.
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Electrochemical Energy Conversion And Storage - An Introduction

by Rudolf (Tu Chemnitz, Germany) Holze e Yuping (Nanjing Tech University, China) Wu

101,39€ + 10% CARD

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 This first textbook on the topic provides a clear and well-structured description of the fundamentals, as well as an excellent overview of the practical applications. The well-structured didactic style guides readers, who can test their understanding with questions and answers.
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Handbook Of Self-Cleaning Surfaces And Materials - From Fundamentals To Applications

337,97€ + 10% CARD

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 This first truly comprehensive work on this hot topic in divided into two easy-to-follow and clearly structured volumes. The first covers the fundamentals while the second volume illustrates a wide range of different applications, including self-cleaning glass, tiles, textiles, paints, and antibacterial materials.
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Drug Selectivity - An Evolving Concept In Medicinal Chemistry

201,40€ + 10% CARD

 An Evolving Concept in Medicinal Chemistry. Find out why unselective drugs outperform ones that are too selective Aiming broadly is the new paradigm for drug development in most major diseases.
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Data Mining In Drug Discovery

198,75€ + 10% CARD

 Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientific data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine.
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Scaffold Hopping In Medicinal Chemistry

178,88€ + 10% CARD

 Your drug candidate isn't safe or patentable? The solution may be just a short hop away! Professional drug developers use real-world examples to demonstrate how every medicinal chemist can be more creative and more successful through scaffold-based design of molecules.
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Drug Metabolism Prediction

212,00€ + 10% CARD

 The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles.
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Thermodynamics And Kinetics Of Drug Binding

178,88€ + 10% CARD

 This practical reference for medicinal and pharmaceutical chemists combines the theory of binding kinetics & thermodynamics with modern experimental and computational methods as well as several case studies from recent lead finding and optimization projects.
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Antitargets And Drug Safety

186,83€ + 10% CARD

 This practical referene for drug developers addresses the most common antitarget-related side effects, including hepatic, cardiovascular, kinase- and GPCR-mediated toxicity. Current strategies how to manage side effects as well as several case studies are included.
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Predictive Toxicology - From Vision To Reality

178,88€ + 10% CARD

 Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment.
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Natural Products In Medicinal Chemistry

192,06€ + 10% CARD

 Well-documented case studies from recent drug development projects highlight the current and future importance of natural products as drug precursors, including much valuable practical knowledge for medicinal chemists working in or entering the field.
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Lead Generation - Methods And Strategies

340,53€ + 10% CARD

 The complete picture of methods and strategies in industrial and academic lead finding and optimization, covering standard as well as novel approaches and highlighting their strengths and weaknesses. Includes several case studies of recent successful lead generation projects.
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Medicinal Chemistry Approaches To Personalized Medicine

178,88€ + 10% CARD

 The prime knowledge resource for drug developers, this handbook contains case studies from the first generation of "personalized drugs" in cancer, neuroscience and inflammation, highlighting the challenges and opportunities of personalized medicine for pharmaceutical development.
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In Vivo Models For Drug Discovery

192,13€ + 10% CARD

 How can animal models contribute to the early drug development process, from target validation to lead profiling? Pharmaceutical industry experts discuss the opportunities for novel drug development as well as the scientific and regulatory pitfalls along the path to success.
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Transporters As Drug Targets

178,88€ + 10% CARD

 As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology.
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Phosphodiesterases And Their Inhibitors

176,23€ + 10% CARD

 Written by the pioneers of the sildenafil (Viagra) phosphodiesterase inhibitor drug, this timely reference discusses emerging applications of novel PDE inhibitors in a variety of disease fields with contributions from major pharmaceutical companies.
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Fragment-Based Drug Discovery - Lessons And Outlook

186,83€ + 10% CARD

 The secret of success in drug discovery written by the pioneers in the field with unrivaled experience in fragment-based methods. In this handbook, the first-hand knowledge imparted by the world's leading experts provides a comprehensive overview of current methods and applications of fragment-based discovery.
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