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Membrane Fluidity - Biophysical Techniques And Cellular Regulation

by Arnisa Kuksis e Morris Kates

118,59€ + 10% CARD

 This book represents the proceedings of a Satellite Symposium of the XIth International Congress of Biochemistry on "Control of Membrane Fluidity" which was held on July 7, 1979 at the Charles H.
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Methods In Protein Sequence Analysis

by Marshall Elzinga

237,84€ + 10% CARD

 Methods in Protein Sequence Analysis contains an intensely prac- tical account of all the new methodology available to scientists carrying out protein and peptide sequencing studies.
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Inflammatory Diseases And Copper - The Metabolic And Therapeutic Roles Of Copper And Other Essential Metalloelements In Humans

by John R. J. Sorenson

237,84€ + 10% CARD

 In 1928, it was discovered that copper was essential for normal human metabolism. A decade later, in 1938, it was observed that patients with rheu- matoid arthritis exhibited a higher than normal serum copper concentration that returned to normal with remission of this disease.
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Directed Drug Delivery - A Multidisciplinary Problem

by Arnold J. Repta, Ronald T. Borchardt e Valentino J. Stella

118,59€ + 10% CARD

 This book is based on the proceedings of the symposium entitled "Di rected Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the sym posium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system re quires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disci plines in identifying the problems and approaches for the develop ment of a rational and effective drug delivery system. Thus the infor mation provided herein will be of value not only to the pharmaceutical chemists who are responsible for dosage form design, but also to the pharmacokineticists, pharmacologists, and clinicians involved in bio logical evaluation of drug delivery systems. The volume should also be of interest to the analytical chemists who must provide technology to quantitcltively evaluate drug delivery. Additionally, this work will also interest the biochemists and medicinal chemists involved in drug dis covery, since the drug delivery system often plays a major role in determining the success or failure of a new drug entity. Each speaker at the symposium was requested to contribute a chapter reviewing the contribution of their major discipline to the de velopment of a successful drug delivery system.
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Inositol And Phosphoinositides - Metabolism And Regulation

by George Hause, John E. Bleasdale e Joseph Eichberg

237,84€ + 10% CARD

 The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides. The first took place in 1968 in New York [Ann. New York Acad. Sci. (1969), 765,508-819] and the second was held in 1977 in East Lansing, Michigan [eyclitols and Phosphoinositides, Wells, W. W. and Eisenberg, F. , eds. , (1978) Academic press, New York, pp. 1-607. ] In the interim since the previous conference, not only has the pace of research in the field accelerated markedly, but the physiological importance of phosphoinositide metabolism has become apparent to an increasing number of investigators from diverse fields in the life sciences. Thus it seemed to us timely for both recent and established workers in this area, as well as others whose interests impinged on it, to meet in order to disseminate new information, to review, and perhaps arrive at, a consensus of our current understanding of the role of inositol and phosphoinositides, and to establish new directions for research for the next few years. The expansion of the field since the last meeting made it mandatory to restrict the scope of the topics covered at the conference, primarily to aspects dealing with mammalian systems. We sincerely regretted the exclusion of recent research on cyclitols and phosphoinositides in microbes and plants and hope that these areas will be included in future conferences.
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Vitamins And Cancer - Human Cancer Prevention By Vitamins And Micronutrients

by Jr. Meyskens e Kedar N. Prasad

118,59€ + 10% CARD

 In the past five years, a surprising and intense resurgence in interest in vitamins and other micronutrients and their role in health and dis- ease has occurred.
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Molecular Basis Of Lymphokine Action

by Carl W. Pierce, David R. Webb e Stanley Cohen

237,84€ + 10% CARD

 The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was ''The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.
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Epstein-Barr Virus And Human Disease

by D. V. Ablashi, G. R. Pearson, M. Nonoyama, P. H. Levine e R. Glaser

237,84€ + 10% CARD

 Since its discovery as the cause of infectious mononucleosis in 1964, the Epstein-Barr virus (EBV) has been etiologically implicated in an increasing number of human diseases. Generally considered the first human oncogenic virus because of a number of studies linking it with Burkitt''s lymphoma and nasopharyngeal carcinoma (NPC), as well as its documented oncogenicity in nonhuman primates, EBVhas served as a model for identifying subsequent candidate oncogenic viruses and the stimulus for Evans'' revision of the Henle-Koch postulates to accommodate the problems in proving viral oncogenicity in humans. Research on the role of EBV in human cancer was particularly en hanced (a) by the pioneering work of Werner and Gertrude Henle, and (b) by the coordinated efforts of the Special Virus Leukemia Program and its successors, the Special Virus Cancer Program and the Virus Cancer Program of the National Cancer Institute (NCI). Initiated by Dr. Frank J. Rauscher, who subsequently became director of the Ncr and is now Vice-President of the American Cancer Society, and expanded by Dr. John B. Moloney, whose contributions to cancer research were honored at this Second International Symposium on EBV and Associated Malignant Diseases, these NCI contract-sup ported programs brought together investigators from all over the world to participate in a joint effort to unravel the mystery of EBV behavior and pathogenicity. It was these programs that gave us the opportunity to work with such outstanding people as Professor Yohei Ito, to whom this book is dedicated.
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Epstein-Barr Virus And Human Disease * 1988

237,84€ + 10% CARD

 The major target cell for EBV infection has now been conclusively identified as the complement receptor-type 2 (CR2), the Cd/Cdg 3 3 receptor on B lymphocyte. It is apparent, however, that other cells also can become infected by EBV, such as epithelial cells in the parotid gland and other epithelial cells in the upper respiratory tract.
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Lactoferrin - Interactions And Biological Functions

171,59€ + 10% CARD

 The number of investigators focusing their attention on lactoferrin has increased dramatically in recent years. Lactoferrin is a protein with more than one known structure and a number of proposed biological functions, including several with important regulatory consequences. In many ways it has been an easy pro tein to investigate; however, there have been difficulties under standing specific structure / function relationships, particularly as it functions in vivo. Research funding dedicated to this protein has previously been limited, but is now increasing. As lactoferrin begins to emerge formally as a protein of significance to the medi and industry, it is more important than ever to coor cal profession dinate and integrate research efforts whenever possible and to share the results of these efforts within the expanding array of medical and scientific diSciplines involved. It was our intention to provide a forum to summarize and disseminate the most recent advances in this field. Included in Lactoferrin: Interactions and Biological Functions are selected presentations representing the many disciplines involved in defining lactoferrin function in terms of its known structural features, including its carbohydrate side-chains, receptor binding sites, its capacity to bind different metal ions, and other newly discovered bioactive domains. Several of the possible physiologi cal functions of lactoferrin are described and summarized in detail, including the role of laetoferrin in bacterial killing, its in volvement in cell growth and proliferation, in the modulation of immune function, and in iron absorption.
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Epstein-Barr Virus And Human Disease * 1990

171,59€ + 10% CARD

 The Epstein-Barr virus (EBV), isolated in 1966, continues to draw worldwide attention as an important human pathogen. The second international symposium was held in St. Petersburg, Florida, in 1986, and was attended by approximately twice as many partici- pants as attended the Loutraki meeting.
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Nutrients In Cancer Prevention And Treatment

by Kedar N. Prasad, Leonida Santamaria e R. Michael Williams

118,59€ + 10% CARD

 Nutrients in Cancer Prevention and Treatment contains articles that were presented by leading researchers and physicians in the field of nutritional oncology. Nutrients in Cancer Prevention and Treatment also contains several studies on the role of diet and vitamins in cancer treatÂ ment.
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Methods In Protein Sequence Analysis * 1986

by Kenneth A. Walsh

237,84€ + 10% CARD

 Methods in Protein Sequence Analysis -1986 brings together reports of the most recent methodology available to protein chemists for studying the molecular detail of proteins.
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Ir Genes - Past, Present, And Future

by Benjamin D. Schwartz, Carl W. Pierce, Donald C. Shreffler, Judith A. Kapp e Susan E. Cullen

171,59€ + 10% CARD

 The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982;
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Regulation Of Immune Gene Expression

by Andrew Mcmichael e Marc Feldmann

118,59€ + 10% CARD

 The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens.
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Biological Methylation And Drug Design - Experimental And Clinical Role Of S-Adenosylmethionine

by Cyrus R. Creveling, Per Magne Ueland e Ronald T. Borchardt

237,84€ + 10% CARD

 This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans methylation inhibitors (Section E).
ENGLISH

International Symposium: Retroviruses And Human Pathology

by Dominique Stehelin, Oliviero E. Varnier e Robert C. Gallo

237,84€ + 10% CARD

 For decades retroviruses have been riding the crest of a wave of experimental research directed toward the identification of an infectious agent of human neoplastic diseases.
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Human T Cell Clones - A New Approach To Immune Regulation

by James N. Woody, Jonathan R. Lamb e Marc Feldmann

118,59€ + 10% CARD

 Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e.
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Immune Regulation

by Marc Feldmann e N. A. Mitchison

237,84€ + 10% CARD

 But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some- times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference?
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Biology Of Copper Complexes

by John R. J. Sorenson

237,84€ + 10% CARD

 In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in flammation appeared twenty-two years after the discovery of essen tiality. In 1976, it was suggested that the active forms of the anti arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis ease states. The presentations and interactive discussions that fol lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.
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Nutrients And Cancer Prevention

by Frank L. Meyskens Jr. e Kedar N. Prasad

118,59€ + 10% CARD

 During the last 10 years, the role of specific nutrients in cancer prevention and cancer treatment has been the subject of intense basic, preclinical, and clinical research.
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Molecular Mechanisms Of Alcohol - Neurobiology And Metabolism

by Albert Y. Sun, Grace Y. Sun, P. Kevin Rudeen, W. Gibson Wood e Yau Huei Wei

237,84€ + 10% CARD

 Alcohol abuse throughout the world is associated with serious social and medical implications. Problems such as intoxication, tol erance, and development of physical dependence have been well recognized. The central nervous system and the liver are especially affected. There is little doubt that alcohol abuse can result in organ damage, which in turn leads to deleterious health consequences to the individual. Understanding ethanol action presents a special and functional diver challenge because of its molecular simplicity sity. In fact, the ability for alcohol to disrupt cellular function is at tributed to its cellular injury without regard to an apparent specific mechanism of action. Nevertheless, the key to an effective treatment to this problem is through research into understanding the mechan isms underlying how ethanol interacts with cells and membranes. This book is the result of a cooperative effort among scientists from many nations who met in a symposium in Taipei, Taiwan, ROC, July 1988. The focus of this book is on experimental ap proaches to better understand the molecular mechanisms of ethanol on the biological system. These recent advances in the examination of the alcohol effects on cellular function are divided into four sec tions. The first section addresses specific actions of ethanol on the central nervous system. The second section is directed to the use of cell cuI tures in ethanol research and the usefulness of cell cultures in examination of the effects of ethanol in vitro.
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Neoplastic Transformation In Human Cell Culture - Mechanisms Of Carcinogenesis

by Anatoly Dritschilo e Johng S. Rhim

131,84€ + 10% CARD

 Mechanisms of Carcinogenesis.
ENGLISH

Nutrients In Cancer Prevention And Treatment

by Kedar N. Prasad, Leonida Santamaria e R. Michael Williams

121,66€ + 10% CARD

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 Nutrients in Cancer Prevention and Treatment contains articles that were presented by leading researchers and physicians in the field of nutritional oncology. Nutrients in Cancer Prevention and Treatment also contains several studies on the role of diet and vitamins in cancer treatÂ ment.
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