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Circulating Tumor Cells - Advances In Liquid Biopsy Technologies

264,34€ + 10% CARD

 It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).CTC play a central role in tumor dissemination and metastasis,and have been established as an important evaluative and research tool in advanced cancer, and potentially important in early stage disease. CTC defines tumor cells circulating in blood, while Disseminated Tumor Cells (DTC) refers to tumor cells identified in bone marrow. CTC/DTC are extremely rare events, even in late stage cancer, and their detection has presented enormous technical challenges, with the emergence of multiple technologies developed to address these challenges, including enrichment, identification and sophisticated analytical techniques to evaluate CTC and other cells in circulation that may also be important in the biology of metastasis.As foundational as CTC/DTC has been, the field of liquid biopsy has expanded well beyond these analytes. The relevance of circulating nucleic acids derived from tumor cells has quickly progressed from research to the clinic. There are now well established clinical applications for using ctDNA/RNA to determine therapeutic targets, follow disease progression and detect cancer recurrence long before routine clinical methods. One of the most exciting new areas of work is the possibility of using these circulating tumor derived nucleic acids to detect cancer at its earliest and potentially most curable stages. Another new and burgeoning area is the detection and analysis of ctExosomes. These highly abundant particles which are actively secreted from tumor (and indeed all) cells represent a novel way to detect and define multiple analytes of importance, including proteins, DNA and meDNA, RNA, miRNA, and other cell components that are protected and preserved in these compact structures.This second edition of Circulating Tumor Cells: Advances in Liquid Biopsy Technologies is entirely new and brings together leaders and innovators in the field of liquid biopsy, including basic and molecular biologists, chemists, engineers, statisticians, experts in tumor banking, test developers, research administrators and clinicians. A special feature of this book is that it includes chapters from the members of the US National Cancer Institute Liquid Biopsy Consortium. This edition also includes many of the participants of the latest international meeting on the Advances in Circulating Tumor Cells (ACTC) which is held in Greece every two years and gathers the most important liquid biopsy investigators from around the world. Thus, this edition represents the most comprehensive and up-to-date resource for those who want to further explore the exciting field of CTC and other liquid biopsy technologies. The new edition will be useful to a wide audience including scientists studying metastasis, cancer researchers, translational scientists, oncologic surgeons, medical oncologists, members of the biopharmaceutical industry, and graduate and undergraduate students studying cancer biology.
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Lung Cancer - New Understandings And Therapies

135,18€ + 10% CARD

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 Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach.
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Engineering And Physical Approaches To Cancer

264,34€ + 10% CARD

 Engineering and Physical Approaches to Cancer addresses the newest research at this interface between cancer biology and the physical sciences. Several chapters address the mechanobiology of collective and individual cell migration, including experimental, theoretical, and computational perspectives. Other chapters consider the crosstalk of biological, chemical, and physical cues in the tumor microenvironment, including the role of senescence, polyploid giant cells, TGF-beta, metabolism, and immune cells. Further, chapters focus on circulating tumor cells and metastatic colonization, highlighting both bioengineered models as well as diagnostic technologies. Further, this book features the work of emerging and diverse investigators in this field, who have already made impressive cross-disciplinary scientific contributions. This book is designed for a general audience, particularly researchers conversant in cancer biology but less familiar with engineering (and vice-versa). Thus, we envision that this book will be suitable for faculty, postdoctoral fellows, and advanced graduate students across medicine, biological sciences, and engineering. We also anticipate this book will be of interest to medical professionals and trainees, as well as researchers in the pharmaceutical and biomedical device industry. Describes physical aspects of cancer, including collective cell migration, the aberrant tumor microenvironment, circulating tumor cells, and metastatic colonization.First volume available on the topic of physical aspects of cancer
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Computational Modeling Of Tensegrity Structures - Art, Nature, Mechanical And Biological Systems

by Buntara Sthenly Gan

94,62€ + 10% CARD

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 Combining a chapter on the analyses of tensegrity structures along with sections on computational modeling, design, and the latest applications of tensegrity structures, the book is ideal for R&D engineers and students working in a broad range of disciplines interested in structural design.
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Targeted Therapies For Lung Cancer

148,70€ + 10% CARD

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 This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer.
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D-Type Cyclins And Cancer

121,66€ + 10% CARD

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 This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins.
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Lung Cancer - New Understandings And Therapies

131,84€ + 10% CARD

 Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach.
ENGLISH

Lung Cancer - New Understandings And Therapies

175,73€ + 10% CARD

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 Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach.
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Targeted Therapies For Lung Cancer

145,09€ + 10% CARD

 This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer.
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Microbiome And Cancer

184,84€ + 10% CARD

 Additional areas will include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin's and non-Hodgkin's lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers.
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Molecular Determinants Of Head And Neck Cancer

175,73€ + 10% CARD

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 Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies.
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Molecular Determinants Of Head And Neck Cancer

171,59€ + 10% CARD

 Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies.
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High Velocity Microparticles In Space - Influence Mechanisms And Mitigating Effects Of Electromagnetic Irradiation

by Anatoly Belous, Siarhei Shvedau e Vitali Saladukha

121,66€ + 10% CARD

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 This book describes for readers the protection of electronic hardware in space vehicles from the negative effects of space dust and electromagnetic irradiation.
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Asbestos And Mesothelioma

148,70€ + 10% CARD

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 Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.
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Future Directions In Well-Being - Education, Organizations And Policy

74,34€ + 10% CARD

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 This book is a collection of essays advancing the discourse in well-being science, authored by key thought leaders in positive psychology and its variants, including positive education, character education, and positive organizational scholarship.
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Advances In Biology And Treatment Of Glioblastoma

175,73€ + 10% CARD

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 This volume covers the most important areas of glioblastoma â€" surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma.
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Mathematical Analysis And The Mathematics Of Computation

by Thomas Zeugmann e Werner Romisch

101,38€ + 10% CARD

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 It develops the relevant theory at a modern level and it directly relates modern mathematical ideas to their diverse applications. The authors develop the whole theory.
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Circulating Tumor Cells

175,73€ + 10% CARD

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 It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream.
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Molecular Determinants Of Head And Neck Cancer

175,73€ + 10% CARD

free shipping

 Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies.
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D-Type Cyclins And Cancer

118,59€ + 10% CARD

 This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins.
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Early Phase Cancer Immunotherapy

171,59€ + 10% CARD

 This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.
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Cancer Associated Viruses

243,33€ + 10% CARD

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 This volume offers a comprehensive review of tumor virology. It examines the many aspects of cancer-related viruses and how they contribute to cell proliferation, the genes that are responsible for driving these cancers, and their mechanisms of transmission.
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Targeting Autophagy In Cancer Therapy

118,59€ + 10% CARD

 This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research.This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
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Asbestos And Mesothelioma

145,09€ + 10% CARD

 Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.
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