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Nuclear Import And Export In Plants And Animals

by Tzvi Tzfira e Vitaly Citovsky

175,73€ + 10% CARD

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 Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA.
ENGLISH

E-Cell System - Basic Concepts And Applications

135,18€ + 10% CARD

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 The purpose of E-Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E-Cell System version 3 in terms of the software features and its usage.
ENGLISH

Arachidonic Acid In Cell Signaling

by Daniele Piomelli

118,59€ + 10% CARD

 This book is about the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in signal transduction.
ENGLISH

Calreticulin

118,59€ + 10% CARD

 This book is about calreticulin, a multifunctional calcium binding protein first discovered over 20 years ago. The protein has been described in various locations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cell surface and even secreted into the blood stream. This volume outlines the newly discovered functions for calreticulin including its control of calcium homeostasis, modulation of steroid-sensitive gene expression, control of viral RNA replication, modulation of nuclear transport, role in T lymphocyte activation and cytotoxic killing, chaperone function, control of adhesion-dependent signaling via integrins, possible role in the biology of ticks, in the pathology of autoimmune diseases and in blood function.
ENGLISH

Aminopeptidases

59,61€ + 10% CARD

 This book summarizes recently gathered information regarding the aminopeptidases. Nomenclature, distributions in the plant and animal kingdoms, structural and compositional information, mechanistic studies, homologies, physiological, medical and industrial uses, and molecular genetics of aminopeptidases are described.
ENGLISH

Calcium And Calmodulin Function In The Cell Nucleus

by Neus Agell e Oriol Bachs

118,59€ + 10% CARD

 This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types. Prominent among these calcium binding proteins is calmodulin, which appears to be involved in the regulation of major nuclear functions such as gene expression and DNA replication.
ENGLISH

G Protein-Coupled Receptors

by John Shine, Tiina P. Iismaa e Trevor J. Biden

59,61€ + 10% CARD

 This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins).
ENGLISH

Ige Receptor (Fceri) Function In Mast Cells And Basophils

118,59€ + 10% CARD

 The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.
ENGLISH

Interleukin-10

59,61€ + 10% CARD

 The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.
ENGLISH

Intracellular Signal Transduction: The Jak-Stat Pathway

by Ailsa G. Harpur e Andrew F. Wilks

118,59€ + 10% CARD

 This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
ENGLISH

Mhc Ligands And Peptide Motifs

by Hans-Georg Rammensee, Jutta Bachmann e Stefan Stevanovic

118,59€ + 10% CARD

 This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
ENGLISH

Organellar Proton-Atpases

by Nathan Nelson

59,61€ + 10% CARD

 THE WORLD OF PROTON PUMPS Nathan Nelson uite frequently an observer looks at a life phenomenon and asks ~himself why nature took this route out of several other available mec anisms. In order to understand this challenge he may first try to reconstruct the evolution of the process taking into account the main driving forces that were assumed to exist during the last 3. 5 billion years on earth. Now we know that the electrochemical gradient of protons is the universal high-energy intermediate produced and uti lized by every living cell in nature. This high energy intermediate is an expression of different concentrations of active protons in the two faces of biological membranes. Why then did nature elect to utilize a pre dominantly electrochemical gradient of protons and no other ion? The answer to this question may lie in the environment in which the first living creatures evolved. Some of them may have been challenged by an acidic environment that lowered their internal pH (by a proton leak through their membranes) to lethal levels. To counteract these inci dents proton pumps evolved. Two independent systems were devel oped. One was a proton pump coupled to energetically downhill vectorial electron transport across membranes and the second was an ATP-dependent proton pump. Both of them pump protons outward from the cells generating an electrochemical gradient of protons.
ENGLISH

P53 Suppressor Gene

by Jack A. Roth, Steven A. Maxwell e Tapas Mukhopadhyay

118,59€ + 10% CARD

 This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.
ENGLISH

Pre-Mrna Processing

59,61€ + 10% CARD

 he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.
ENGLISH

Protein Toxin Structure

118,59€ + 10% CARD

 Joseph E. Alouf "The empirical basis of objective science has thus nothing ''abso lute'' about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or ''given'' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being. " -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox ins. The present book attempts for the first time to provide into one volume a series of chapters prepared by invited experts on the struc ture of these fascinating macromolecules. A particular emphasis is placed on the molecular features of these highly active biomolecules in rela tion to their biological properties and mechanisms of action. The researchers in bacterial protein toxinology of my generation have had the privilege of witnessing over 40 years the tremen dous development of this field of biological sciences, particularly in the past decade.
ENGLISH

Sphingolipid-Mediated Signal Transduction

59,61€ + 10% CARD

 Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.
ENGLISH

Human T-Cell Receptor Repertoire And Transplantation

118,59€ + 10% CARD

 these analyses it became clear that the MHC class I molecule com- prised a distinct groove on the external side of the molecule. * *- High resolu- tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules.
ENGLISH

Meaning Of Nucleocytoplasmic Transport

by Paul S. Agutter e Philip L. Taylor

59,61€ + 10% CARD

 The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.
ENGLISH

Unusual Secretory Pathways: From Bacteria To Man

59,61€ + 10% CARD

 This book constitutes the first comprehensive discussion and collection of facts and functions of unconventional secretory pathways, some of which are of importance in human disease and pathology. The function of ABC transporters in these processes is also discussed. This comparison of common aspects and similarities in all living cells - from bacteria to man - is an excellent reference book with "textbook" character.
ENGLISH

Wilms Tumor: Clinical And Molecular Characterization

by Bryan Williams, Christine E. Campbell e Max J. Coppes

59,61€ + 10% CARD

 WT1 is a DNA Binding Protein Containing Four C2H2 Zinc Fingers . 113 WTI Mutations in Wilms Tumor . 114 Analysis of WTI Mutations in Tumors Other than Wilms Tumor . 137 Nephrogenic Rests, WTI Mutations and Wilms Tumor . 141 Wilms Tumor and Beckwith-Wiedemann Syndrome . 144 Wilms Tumor and Li-F raumeni Syndrome .
ENGLISH

Stage-Structured Populations - Sampling, Analysis And Simulation

by Bryan Manly

59,61€ + 10% CARD

 The topics covered are sam- pling designs (Chapter 2), the estimation of parameters by maximum likelihood (Chapter 3), the analysis of sample counts of the numbers cif individuals in different stages at different times (Chapters 4 and 5), the analysis of data using Leslie matrix types of model (Chapter 6) and key factor analysis (Chapter 7).
ENGLISH

Statistics Of Natural Selection On Animal Populations

by Brian F. Manly

59,61€ + 10% CARD

 In the concluding chapter of his famous book on the theory of evolution by natural selection, Charles Darwin (1859) remarked that: When the views entertained in this volume on the origin of species, or when analogous views are generally admitted, we can dimly foresee that there will be a considerable revolution in natural history. This proved, of course, to be completely correct. At present there is a great divergence of opinion about the general importance of natural selection in the evolutionary process. Nevertheless, biologists are, on the whole, united in their acceptance of the potential power of selection in changing populations. Given this situation, it is not surprising to find that many attempts to detect the effects of natural selection have been made since the time of Darwin. This area of study has been called ecological genetics. It involves the collection of data of various kinds and, in many cases, the development of special methods for analysing these data. This book is a summary of methods for data analysis, concentrating on those that are applicable to animal populations, particularly wild populations.
Chiral Liquid Chromatography

60,82€ + 10% CARD

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 While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC).
ENGLISH

Mobile Receptor Hypothesis - The Role Of Membrane Receptor Lateral Movement In Signal Transduction

by David A. Jans

59,61€ + 10% CARD
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