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Principles Of Cardiovascular Neural Regulation In Health And Disease

by Alberto Malliani

~~97,34€~~ 77,87€ 20% OFF

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 Indicates to researchers and clinicians a different way to approach the complexity of cardiovascular neural regulation. This book assesses the complexity of cardiovascular neural regulation, reflected by the state of sympathovagal balance in the frequency domain.
ENGLISH

Principles Of Cardiovascular Neural Regulation In Health And Disease

by Alberto Malliani

~~59,61€~~ 47,69€ 20% OFF

 This book is an attempt to indicate to researchers and clinicians a simple way to approach the complexity of cardiovascular neural regulation.
ENGLISH

Cardiac Cellular Electrophysiology - Southwest Germany In The Late Paleolithic And Mesolithic

by Edward Carmeliet e J. Vereecke

~~171,59€~~ 137,27€ 20% OFF

 Cardiac Cellular Electrophysiology is intended for the clinical cardiologist who wishes to refresh or deepen his understanding of the cellular basis of cardiac electrophysiology, for researchers interested in the basis of the electrical activity of the heart, such as clinical investigators, physiologists or pharmacologists, for teachers in physiology, pharmacology and other biomedical studies, and for medical students from graduate to postgraduate level. Cardiac Cellular Electrophysiology starts with a primer of basic electrophysiology, the cardiac action potential and the physiological basis of the electrocardiogram. Our second aim after having introduced the basic concepts was to continue with giving an overview of the properties of the most important ionic currents in the heart, and to treat their modulation, in order to deal with the mechanisms underlying cardiac ischaemia, arrhythmias and remodelling. Edward Carmeliet and Johan Vereecke, Katholieke University Leuven, Belgium, have collaborated for over 30 years in cardiac electrophysiology research. Their studies include the genesis of the normal action potential, its changes in ischaemia, the effect of drugs, and the mechanism of arrhythmias, using techniques from the classic potential registration with intracellular microelectrodes to whole cell clamp and single channel measurements.
ENGLISH

Role Of Potassium In Preventive Cardiovascular Medicine

by David B. Young

~~171,59€~~ 137,27€ 20% OFF

 Role of Potassium in Preventive Cardiovascular Medicine: Information related to this question has accumulated for nearly a hundred years, from work in cellular physiology, experimental studies in animals, clinical trials, and from population and epidemiological investigations. Because of the importance of integration of this diverse body of information, the most significant findings are brought together in this book. This body of information provides emphatic support for the importance of high dietary potassium intake as a means of reducing the risk of cardiovascular diseases, as it provides abundant evidence that potassium depletion has significant, deleterious influences that increase the risk of hypertension, atherosclerosis, heart failure, and stroke. At this time we have the results and data required to strongly recommend dietary modification to increase potassium intake. But making the recommendation will only be the first step; convincing the population to undertake the change in eating patterns will be challenging, and will require concerted actions by government, the medical community, and the food and beverage industries. The outcome promises to be well worth the investment. `This book is an excellent source of current information on the many roles of potassium in cardiovascular disease. It succinctly mixes basic physiology and clinical aspects in a manner that will make it of great value to both researchers and clinicians.'' Norman M. Kaplan, M.D., Professor of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
ENGLISH

Coronary Flow Reserve - Measurement And Application: Focus On Transthoracic Doppler Echocardiography

by Pawel Petkow-Dimitrow

~~118,59€~~ 94,87€ 20% OFF

 Coronary flow reserve is an important functional parameter to understand the pathophysiology of coronary circulation. Coronary flow reserve measurement is used to assess epicardial coronary stenoses or to examine the integrity of microvascular circulation. An appreciation of coronary physiology is an integral part of clinical decision-making for cardiologists treating patients with coronary artery disease. The pioneering research efforts of Dr Lance Gould, who explored the relationship between the anatomic severity of a stenosis and its flow resistance (59;60) , have been transferred to clinical practice (94; 194). In the absence of stenosis in epicardial coronary artery, the coronary flow reserve may be decreased when coronary microvascular circulation is compromised by arterial hypertension with or without left ventricular hypertrophy, diabetes mellitus, hypercholesterolemia, or other diseases. Several techniques have been established for measuring coronary flow reserve. However, these techniques are either invasive (intracoronary Doppler flow wire), highly expensive and scarcely available (Positron Emission Tomography - PET) or semi-invasive and causing patient discomfort (transesophageal Doppler echocardiography), thus their clinical use is limited. Because of the clinical importance of coronary flow reserve there is a need for a simple, noninvasive, repeatable and inexpensive tool capable of this functional evaluation. This monograph focuses on the assessment of coronary flow reserve using transthoracic Doppler echocardiography - the technique fulfilling the above-mentioned criteria. Transthoracic Doppler echocardiography has become a popular tool evolving from a research to diagnostic technique applied in everyday practice.
ENGLISH

Clinical Physiology Of The Venous System

by Francisc A. Schneider, Ioana Raluca Siska e Jecu Aurel Avram

~~171,59€~~ 137,27€ 20% OFF

 Clinical Physiology of the Venous System is a comprehensive overview of vein physiology. - Presents data in the fields of venous physiology, pharmacology and venous diseases as well as the field of phlebology, which has seen rapid and important progress in the last decade.
ENGLISH

Molecular Cardiology In Clinical Practice

~~171,59€~~ 137,27€ 20% OFF

 Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new `molecular'' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.
ENGLISH

Cardiac Ischemia: From Injury To Protection

~~171,59€~~ 137,27€ 20% OFF

 Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
ENGLISH

Genetics Of Dyslipidemia

by Pascale Benlian

~~171,59€~~ 137,27€ 20% OFF

 Profound mortality rates, due to cardiovascular disease, are a worldwide problem. Cardiovascular disease results from complications of a silent and chronic arterial disease: atherosclerosis.
ENGLISH

Heart Cell Coupling And Impulse Propagation In Health And Disease

~~171,59€~~ 137,27€ 20% OFF

 Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions.
ENGLISH

Atp And The Heart

by Joanne S. Ingwall

~~171,59€~~ 137,27€ 20% OFF

 ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.
ENGLISH

Genetics And Genomics For The Cardiologist

by Gian Antonio Danieli

~~118,59€~~ 94,87€ 20% OFF

 Genetics and Genomics for the Cardiologist is a concise, but comprehensive volume for the clinical cardiologist or medical student interested in learning how molecular genetics is now being applied to prevention and treatment of heart diseases, from DNA tests to pharmacogenomics and gene-based therapeutics.
ENGLISH

Mechanics And Energetics Of The Myocardium

by Christian J.F. Holubarsch

~~171,59€~~ 137,27€ 20% OFF

 During several decades of this century, the classical physiological studies on the cardiovascular system have greatly improved our knowledge on the function of this system under normal and pathological conditions. This knowledge was the basis of the breakthrough for diagnostic techniques like the Swan-Ganz catheter, coronary arteriography, left and right heart biopsies, and invasive measurements of contractility, as well as therapeutic tools including aortocoronary bypass surgery, percutanous transluminal coronary angioplasty, and a broad field of pharmacological interventions for the whole spectrum of cardiovascular diseases, especially chronic heart failure. It was during the last decade that the scientific world focused on the evolution of molecular biology of the cardiovascular system so that cardiovascular physiology seemed to become less important. Regarding the myocardium, molecular alterations of important functional proteins (phenotype changes), as well as signal transduction pathways of contractility and cardiac growth have been elucidated. The functional importance of a number of genes has undoubtedly been proven with the help of transgenic animals. Mechanics and Energetics of the Myocardium provides an overview for those researchers and practioners interested in the broad field of molecular biology and physiology of the cardiovascular system.
ENGLISH

Physiological Genomics Of The Critically Ill Mouse

~~118,59€~~ 94,87€ 20% OFF

 The physiological genomics of the cardiovascular system studies the relationship between gene and physiological (dys)function. In the past, the mouse had mainly been used in the area of immunology and molecular biology, and physiological interest in the mouse was scarce.
ENGLISH

Biology Of The Arterial Wall

~~171,59€~~ 137,27€ 20% OFF

 Biology of the Arterial Wall is intended as a general reference text concerned with the biology of the vascular cells and the blood vessel wall under physiological and pathological conditions. One of the major functions of the arteries is to maintain a continuous blood flow to the organs whatever the pressure conditions, thanks to the vasomotor tone of the smooth muscle cells. Great advances have been made over the last decade in the understanding of the endothelial cells as integrators and transducers of signals originating from the blood stream. The pluripotent control functions of the endothelial cells in the vessel wall are now well recognized. A review of endothelial functions and dysfunctions is presented. Cell biology and molecular genetic studies have now identified an array of molecules elaborated by endothelial cells and vascular smooth muscle cells and by the blood-borne elements which interact with artery cells, defending the artery against injury and modulating evolving abnormal processes. Molecules which induce or inhibit endothelial and/or smooth muscle cells are currently under great scrutiny. Angiogenesis, which plays a major role in tumor growth, but may also be beneficial as a healing process in muscle ischemia, is discussed. Apoptosis, or programmed cell death, has only recently been recognized as an essential process in blood vessel modeling and remodeling. An overview of apoptosis in the vascular system is presented. It is increasingly evident that the adjustments of the blood vessel wall are made in the presence of deforming disease processes such as hypertension and atherosclerosis. The second part of the book is concerned with the blood vessel wall in disease conditions. Several chapters review the role of the vessel and vascular cells in inflammation, and vascular remodeling during arterial hypertension and aging. One chapter is devoted to atherogenesis, atheroma and plaque instability, followed by the pathophysiology of post-angioplasty restenosis, which is a crucial issue in modern interventional cardiology.
ENGLISH

Apoptosis In Cardiac Biology

~~237,84€~~ 190,27€ 20% OFF

 Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease.
ENGLISH

Clinical Physiology Of The Venous System

by Francisc A. Schneider, Ioana Raluca Siska e Jecu Aurel Avram

~~175,73€~~ 140,58€ 20% OFF

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 Clinical Physiology of the Venous System is a comprehensive overview of vein physiology. - Presents data in the fields of venous physiology, pharmacology and venous diseases as well as the field of phlebology, which has seen rapid and important progress in the last decade.
ENGLISH

Coronary Flow Reserve - Measurement And Application: Focus On Transthoracic Doppler Echocardiography

by Pawel Petkow-Dimitrow

~~121,66€~~ 97,33€ 20% OFF

free shipping

 Coronary flow reserve is an important functional parameter to understand the pathophysiology of coronary circulation.
ENGLISH

Genetics Of Dyslipidemia

by Pascale Benlian

~~175,73€~~ 140,58€ 20% OFF

free shipping

 Profound mortality rates, due to cardiovascular disease, are a worldwide problem. Cardiovascular disease results from complications of a silent and chronic arterial disease: atherosclerosis.
ENGLISH

Genetics And Genomics For The Cardiologist

by Gian Antonio Danieli

~~121,66€~~ 97,33€ 20% OFF

free shipping

 Genetics and Genomics for the Cardiologist is a concise, but comprehensive volume for the clinical cardiologist or medical student interested in learning how molecular genetics is now being applied to prevention and treatment of heart diseases, from DNA tests to pharmacogenomics and gene-based therapeutics.
ENGLISH

Local Cardiac Renin-Angiotensin Aldosterone System

~~141,78€~~ 113,42€ 20% OFF

 How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn't until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced the potent octapeptide angiotensin. Several important subsequent findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone system. Further, this system demonstrated a classical biofeedback and the circulating octapeptide was shown to have additional biological activities in organs other than heart, vessels, kidney, adrenals, and even brain.
ENGLISH

Myocardial Ischemia - From Mechanisms To Therapeutic Potentials

~~131,84€~~ 105,47€ 20% OFF

 Tremendous progress has been made in understanding the pathophysiology of ischemic heart disease. This volume highlights issues concerning basic mechanisms of ischemia-reperfusion injury in relation to potential therapeutic strategies.
ENGLISH

Snapshots Of Hemodynamics - An Aid For Clinical Research And Graduate Education

by Mark I.M. Noble, Nico Westerhof e Nikos Stergiopulos

~~171,59€~~ 137,27€ 20% OFF

 Hemodynamics makes it possible to characterize in a quantitative way, the function of the heart and arterial system. This book provides diagrams and descriptions of the essentials of basic and applied principles of hemodynamics. It is intended for basic and clinical researchers, as well as graduate students.
ENGLISH

Adrenomedullin In Cardiovascular Disease

~~131,84€~~ 105,47€ 20% OFF

 Adrenomedullin has attracted considerable interest among cardiologists due to its impact on the cardiovascular system. This book is a review of the relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology and pathophysiology of cardiovascular disease.
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